Source:http://linkedlifedata.com/resource/pubmed/id/10616850
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2000-2-4
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| pubmed:abstractText |
Ischemia/reperfusion injury leads to delayed graft function, which is a major problem in kidney transplantation. This study investigated the effects of adding trimetazidine (TMZ) to the perfusate of cold-stored kidneys on the function of reperfused autotransplanted pig kidney. The left kidney was removed and cold-flushed with Euro-Collins (EC), or University of Wisconsin (UW) solutions with or without 10(-6)M TMZ and stored for 48 h at 4 degrees C. The kidneys were then autotransplanted and the contralateral kidneys were removed. Several parameters were analyzed over the 14 d after transplantation. The survival rate was 57% in pigs transplanted with kidneys cold-flushed with UW and 43% for those flushed with EC solution; it was 100% for pigs having kidneys cold-flushed with TMZ-supplemented UW and EC solutions. The functions of the transplanted kidneys were also better preserved after cold flush with TMZ-supplemented solutions than with TMZ-free solutions. Creatinine clearance was higher and the urinary excretion of trimethylamine-N-oxide and dimethylamine, used as markers of renal medulla injury, were lower in animals transplanted with kidneys cold-flushed with TMZ-supplemented solutions than with TMZ-free solutions. The cytoprotective action of TMZ also reduced interstitial and peritubular inflammation and the numbers of infiltrating mononuclear CD45+and CD3+ T cells. These results indicate that the tissue damage due to ischemia/reperfusion injury may be prevented, at least in part, by adding TMZ to preservation solutions.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Dimethylamines,
http://linkedlifedata.com/resource/pubmed/chemical/Methylamines,
http://linkedlifedata.com/resource/pubmed/chemical/Trimetazidine,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents,
http://linkedlifedata.com/resource/pubmed/chemical/dimethylamine,
http://linkedlifedata.com/resource/pubmed/chemical/trimethyloxamine
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
|
| pubmed:issn |
1046-6673
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
138-48
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:10616850-Animals,
pubmed-meshheading:10616850-Cold Temperature,
pubmed-meshheading:10616850-Dimethylamines,
pubmed-meshheading:10616850-Disease Models, Animal,
pubmed-meshheading:10616850-Graft Rejection,
pubmed-meshheading:10616850-Graft Survival,
pubmed-meshheading:10616850-Kidney,
pubmed-meshheading:10616850-Kidney Function Tests,
pubmed-meshheading:10616850-Kidney Transplantation,
pubmed-meshheading:10616850-Male,
pubmed-meshheading:10616850-Methylamines,
pubmed-meshheading:10616850-Reference Values,
pubmed-meshheading:10616850-Reperfusion Injury,
pubmed-meshheading:10616850-Swine,
pubmed-meshheading:10616850-Transplantation, Autologous,
pubmed-meshheading:10616850-Treatment Outcome,
pubmed-meshheading:10616850-Trimetazidine,
pubmed-meshheading:10616850-Vasodilator Agents
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| pubmed:year |
2000
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| pubmed:articleTitle |
Trimetazidine reduces renal dysfunction by limiting the cold ischemia/reperfusion injury in autotransplanted pig kidneys.
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| pubmed:affiliation |
Unité de Chirurgie Expérimentale, Départment de génétique animale, Institut National de la Recherche Agronomique, Le Magneraud, Surgères, France. hauet@magneraud.inra.fr
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|