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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9197
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pubmed:dateCreated |
2000-1-21
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pubmed:abstractText |
Recurrent epidemics of meningococcal disease have been reported throughout the African meningitis belt since description of the disease in 1912. Meningooccal polysaccharide vaccines can effectively prevent disease but the optimum strategy for their use in this setting has been controversial. We used data from an outbreak of meningococcal disease in northern Ghana in 1997 to assess the potential effect of different vaccination strategies.
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pubmed:commentsCorrections |
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pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Africa,
http://linkedlifedata.com/resource/pubmed/keyword/Africa South Of The Sahara,
http://linkedlifedata.com/resource/pubmed/keyword/Bacterial And Fungal...,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/CENTRAL NERVOUS SYSTEM,
http://linkedlifedata.com/resource/pubmed/keyword/Central Nervous System...,
http://linkedlifedata.com/resource/pubmed/keyword/Delivery Of Health Care,
http://linkedlifedata.com/resource/pubmed/keyword/Developing Countries,
http://linkedlifedata.com/resource/pubmed/keyword/Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/EPIDEMICS,
http://linkedlifedata.com/resource/pubmed/keyword/English Speaking Africa,
http://linkedlifedata.com/resource/pubmed/keyword/Evaluation,
http://linkedlifedata.com/resource/pubmed/keyword/Evaluation Report,
http://linkedlifedata.com/resource/pubmed/keyword/Ghana,
http://linkedlifedata.com/resource/pubmed/keyword/Health,
http://linkedlifedata.com/resource/pubmed/keyword/Health Services,
http://linkedlifedata.com/resource/pubmed/keyword/IMMUNIZATION,
http://linkedlifedata.com/resource/pubmed/keyword/Infections,
http://linkedlifedata.com/resource/pubmed/keyword/Organization And Administration,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Policy Development,
http://linkedlifedata.com/resource/pubmed/keyword/Population At Risk,
http://linkedlifedata.com/resource/pubmed/keyword/Primary Health Care,
http://linkedlifedata.com/resource/pubmed/keyword/Program Evaluation,
http://linkedlifedata.com/resource/pubmed/keyword/Programs,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/VACCINATION,
http://linkedlifedata.com/resource/pubmed/keyword/Western Africa
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0140-6736
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
355
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
30-3
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pubmed:dateRevised |
2004-11-17
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pubmed:otherAbstract |
PIP: This study assessed the potential effects of different vaccination strategies using data from the 1997 meningococcal outbreak in northern Ghana. Since the description of the disease in 1912, recurrent epidemics of meningococcal disease have been reported throughout the African meningitis belt. The use of meningococcal polysaccharide vaccines has been proven to effectively prevent the disease, although the method of vaccine distribution was disputable. Using a simple mathematical model, meningococcal meningitis cases and deaths, which could have been forestalled by vaccination, were identified, and the effect of developed vaccination strategies on the public health system was analyzed. About 18,703 cases and 1356 deaths were reported in 3 regions of northern Ghana between November 1996 and May 1997. Vaccination was conducted between February and April, which covered 72% of the high-risk population and prevented approximately 23% of cases and 18% of deaths. Routine childhood and adult immunization would have prevented 61% of cases had this same rate of vaccine coverage been achieved and maintained before the epidemic. This study suggests that the prevention of the meningococcal disease epidemic in West Africa would be difficult unless long-lasting conjugate vaccines are incorporated into routine infant immunization schedules. For now, the surveillance and response strategies advocated by the WHO serve as an effective and practical intervention.
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pubmed:meshHeading |
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pubmed:year |
2000
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pubmed:articleTitle |
Emergency vaccination against epidemic meningitis in Ghana: implications for the control of meningococcal disease in West Africa.
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pubmed:affiliation |
Epidemic Intelligence Service, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
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pubmed:publicationType |
Journal Article
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