Source:http://linkedlifedata.com/resource/pubmed/id/10615231
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2000-1-4
|
| pubmed:abstractText |
In this multicentre, randomised, double-blind study, the safety and efficacy of oral fluconazole (200 micrograms/day) and nystatin suspension (6,000,000 IU/day) for the prevention of fungal infections were compared in patients with leukaemia undergoing remission induction chemotherapy. Antifungal prophylaxis was initiated at the time chemotherapy was started and continued throughout the hospital stay or the period of neutropenia to a maximum of 42 days. Prophylaxis was successful (no evidence of fungal infection or fever of unknown origin unresponsive to antibiotics) in 38 of 56 (68%) fluconazole-treated and 25 of 53 (47%) nystatin-treated patients (P = 0.03). 2 patients (4%) in the fluconazole group and 6 (11%) patients in the nystatin group developed systemic fungal infections (P = 0.15). The overall frequency of adverse events was similar among fluconazole-treated (29%) and nystatin-treated (32%); most events in both treatment groups involved the gastrointestinal tract. These results indicated fluconazole was more effective than nystatin in preventing Candida infections in patients with leukaemia; fluconazole was well tolerated.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0959-8049
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
35
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1208-13
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:10615231-Acute Disease,
pubmed-meshheading:10615231-Administration, Oral,
pubmed-meshheading:10615231-Adolescent,
pubmed-meshheading:10615231-Adult,
pubmed-meshheading:10615231-Aged,
pubmed-meshheading:10615231-Aged, 80 and over,
pubmed-meshheading:10615231-Antifungal Agents,
pubmed-meshheading:10615231-Candidiasis,
pubmed-meshheading:10615231-Double-Blind Method,
pubmed-meshheading:10615231-Female,
pubmed-meshheading:10615231-Fluconazole,
pubmed-meshheading:10615231-Humans,
pubmed-meshheading:10615231-Leukemia,
pubmed-meshheading:10615231-Male,
pubmed-meshheading:10615231-Middle Aged,
pubmed-meshheading:10615231-Neutropenia,
pubmed-meshheading:10615231-Nystatin,
pubmed-meshheading:10615231-Opportunistic Infections,
pubmed-meshheading:10615231-Treatment Outcome
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
A double-blind comparison of fluconazole and nystatin in the prevention of candidiasis in patients with leukaemia. Antifungal Prophylaxis Study Group.
|
| pubmed:affiliation |
Kanematsu Laboratories, University of Sydney, Royal Prince Alfred Hospital, Camperdown NSW, Australia. graham@kan.rpa.cs.nsw.gov.au
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
|