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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5450
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pubmed:dateCreated |
2000-1-20
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pubmed:databankReference |
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pubmed:abstractText |
Voltage-gated proton (H+) channels are found in many human and animal tissues and play an important role in cellular defense against acidic stress. However, a molecular identification of these unique ion conductances has so far not been achieved. A 191-amino acid protein is described that, upon heterologous expression, has properties indistinguishable from those of native H+ channels. This protein is generated through alternative splicing of messenger RNA derived from the gene NOH-1 (NADPH oxidase homolog 1, where NADPH is the reduced form of nicotinamide adenine dinucleotide phosphate).
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
287
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
138-42
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:10615049-Alternative Splicing,
pubmed-meshheading:10615049-Amino Acid Sequence,
pubmed-meshheading:10615049-Cell Line,
pubmed-meshheading:10615049-Cytosol,
pubmed-meshheading:10615049-Electric Conductivity,
pubmed-meshheading:10615049-Electron Transport,
pubmed-meshheading:10615049-Expressed Sequence Tags,
pubmed-meshheading:10615049-Humans,
pubmed-meshheading:10615049-Hydrogen,
pubmed-meshheading:10615049-Hydrogen-Ion Concentration,
pubmed-meshheading:10615049-Ion Channel Gating,
pubmed-meshheading:10615049-Ion Channels,
pubmed-meshheading:10615049-Membrane Glycoproteins,
pubmed-meshheading:10615049-Molecular Sequence Data,
pubmed-meshheading:10615049-NADPH Oxidase,
pubmed-meshheading:10615049-Patch-Clamp Techniques,
pubmed-meshheading:10615049-Protons,
pubmed-meshheading:10615049-Transfection,
pubmed-meshheading:10615049-Tumor Cells, Cultured,
pubmed-meshheading:10615049-Zinc
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pubmed:year |
2000
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pubmed:articleTitle |
A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1.
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pubmed:affiliation |
Biology of Aging Laboratory, Department of Geriatrics, Geneva University Hospitals, Geneva Medical School, CH-1211 Geneva 4, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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