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pubmed-article:10613613pubmed:abstractTextDextromethorphan and chloroguanide (INN, proguanil) are used as prototypic phenotyping substrates of polymorphically expressed CYP2D6 and CYP2C19 in humans. We determined whether the dextromethorphan/dextrorphan and chloroguanide/cycloguanil metabolic ratios, obtained after administration of the parent drugs either alone or in combination, are equivalent.lld:pubmed
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pubmed-article:10613613pubmed:articleTitleAssessment of CYP2D6 and CYP2C19 activity in vivo in humans: a cocktail study with dextromethorphan and chloroguanide alone and in combination.lld:pubmed
pubmed-article:10613613pubmed:affiliationClinical Investigation Center, St-Antoine University Hospital, and the Department of Pharmacology, Paris, France.lld:pubmed
pubmed-article:10613613pubmed:publicationTypeJournal Articlelld:pubmed
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pubmed-article:10613613pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:10613613pubmed:publicationTypeRandomized Controlled Triallld:pubmed
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