|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0008241,
umls-concept:C0011816,
umls-concept:C0031809,
umls-concept:C0057223,
umls-concept:C0086418,
umls-concept:C0205195,
umls-concept:C0441655,
umls-concept:C0678420,
umls-concept:C1332828,
umls-concept:C1332830,
umls-concept:C1515655,
umls-concept:C2603343
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|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2000-1-4
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|
pubmed:abstractText |
Dextromethorphan and chloroguanide (INN, proguanil) are used as prototypic phenotyping substrates of polymorphically expressed CYP2D6 and CYP2C19 in humans. We determined whether the dextromethorphan/dextrorphan and chloroguanide/cycloguanil metabolic ratios, obtained after administration of the parent drugs either alone or in combination, are equivalent.
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pubmed:grant |
|
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pubmed:language |
eng
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|
pubmed:journal |
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|
pubmed:citationSubset |
AIM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0009-9236
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
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pubmed:volume |
66
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
582-8
|
|
pubmed:dateRevised |
2010-11-18
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|
pubmed:meshHeading |
pubmed-meshheading:10613613-Administration, Oral,
pubmed-meshheading:10613613-Adult,
pubmed-meshheading:10613613-Antimalarials,
pubmed-meshheading:10613613-Antitussive Agents,
pubmed-meshheading:10613613-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:10613613-Cytochrome P-450 CYP2D6,
pubmed-meshheading:10613613-Cytochrome P-450 Enzyme System,
pubmed-meshheading:10613613-Dextromethorphan,
pubmed-meshheading:10613613-Humans,
pubmed-meshheading:10613613-Male,
pubmed-meshheading:10613613-Mixed Function Oxygenases,
pubmed-meshheading:10613613-Proguanil,
pubmed-meshheading:10613613-Reference Values
|
|
pubmed:year |
1999
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|
pubmed:articleTitle |
Assessment of CYP2D6 and CYP2C19 activity in vivo in humans: a cocktail study with dextromethorphan and chloroguanide alone and in combination.
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|
pubmed:affiliation |
Clinical Investigation Center, St-Antoine University Hospital, and the Department of Pharmacology, Paris, France.
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|
