Source:http://linkedlifedata.com/resource/pubmed/id/10612601
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
23
|
| pubmed:dateCreated |
2000-1-13
|
| pubmed:abstractText |
A series of 4-hydroxy-1-[3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl] piperidines was investigated as potential selective h5-HT1D agonists for the treatment of migraine. The 4-[(N-benzyl-N-methyl)amino]methyl analog 12a was found to be a full agonist at the h5-HT1D receptor with good binding selectivity over the h5-HT1B receptor.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
6
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3369-74
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:10612601-Animals,
pubmed-meshheading:10612601-CHO Cells,
pubmed-meshheading:10612601-Cricetinae,
pubmed-meshheading:10612601-Humans,
pubmed-meshheading:10612601-Migraine Disorders,
pubmed-meshheading:10612601-Piperidines,
pubmed-meshheading:10612601-Receptor, Serotonin, 5-HT1D,
pubmed-meshheading:10612601-Receptors, Serotonin,
pubmed-meshheading:10612601-Serotonin Receptor Agonists
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
4-Hydroxy-1-[3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl]piperidines: selective h5-HT1D agonists for the treatment of migraine.
|
| pubmed:affiliation |
Merck, Sharp & Dohme Research Laboratories, Terlings Park, Harlow, UK. Sylvie Bourrain@Merck.com
|
| pubmed:publicationType |
Journal Article
|