Source:http://linkedlifedata.com/resource/pubmed/id/10612590
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
23
|
| pubmed:dateCreated |
2000-1-13
|
| pubmed:abstractText |
In the course of a study of 6-N-amino-substituted analogues of NB-506 (1), a more potent anticancer drug, J-109,404 (2), in which the formyl group of NB-506 was replaced with a 1,3-dihydroxypropane group, was reported. A study of further modification in the positions of two hydroxyl groups at the indole rings of 2 resulted in the discovery of a 2,10-dihydroxy analogue, J-107,088 (3), which is a promising anticancer agent with a broader therapeutic window than J-109,404.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
6
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3307-12
|
| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10612590-Animals,
pubmed-meshheading:10612590-Antineoplastic Agents,
pubmed-meshheading:10612590-Carbazoles,
pubmed-meshheading:10612590-Drug Screening Assays, Antitumor,
pubmed-meshheading:10612590-Glucosides,
pubmed-meshheading:10612590-Humans,
pubmed-meshheading:10612590-Tumor Cells, Cultured
|
| pubmed:year |
1999
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| pubmed:articleTitle |
Synthesis and biological activities of NB-506 analogues: Effects of the positions of two hydroxyl groups at the indole rings.
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| pubmed:affiliation |
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Ibaraki, Japan.
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| pubmed:publicationType |
Journal Article
|