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rdf:type |
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lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0007634,
umls-concept:C0026682,
umls-concept:C0028631,
umls-concept:C0033684,
umls-concept:C0036536,
umls-concept:C0036537,
umls-concept:C0056889,
umls-concept:C0332256,
umls-concept:C0439851,
umls-concept:C0719517,
umls-concept:C1318700,
umls-concept:C1550309,
umls-concept:C1552596,
umls-concept:C1947931,
umls-concept:C2349182
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pubmed:issue |
1-2
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pubmed:dateCreated |
2000-1-24
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pubmed:abstractText |
A selective cyclic nucleotide PDE5 inhibitor corrected the defective mucin secretion response to the beta-agonist isoproterenol in submandibular acinar cells inhibited by antibody directed against the cystic fibrosis transmembrane conductance regulator. The PDE5 inhibitor was as effective as cpt-cyclic AMP or a selective PDE4 inhibitor. However, the PDE5 inhibitor had no effect on basal or isoproterenol-stimulated cyclic AMP levels and did not stimulate mucin secretion. The results showing, for the first time, correction of the CFTR mucin secretion defect by a PDE5 inhibitor, which may involve cyclic GMP, will have a major impact in development of a rational drug treatment for cystic fibrosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-Methyl-3-isobutylxanthine,
http://linkedlifedata.com/resource/pubmed/chemical/2-(2-propoxyphenyl)-6-purinone,
http://linkedlifedata.com/resource/pubmed/chemical/3',5'-Cyclic-GMP Phosphodiesterases,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/CFTR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic Nucleotide...,
http://linkedlifedata.com/resource/pubmed/chemical/Cystic Fibrosis Transmembrane...,
http://linkedlifedata.com/resource/pubmed/chemical/Isoproterenol,
http://linkedlifedata.com/resource/pubmed/chemical/Mucins,
http://linkedlifedata.com/resource/pubmed/chemical/PDE5A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Pde5a protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Purinones,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridazines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Rolipram,
http://linkedlifedata.com/resource/pubmed/chemical/SK&F 95654
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
464
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
48-52
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10611481-1-Methyl-3-isobutylxanthine,
pubmed-meshheading:10611481-3',5'-Cyclic-GMP Phosphodiesterases,
pubmed-meshheading:10611481-Animals,
pubmed-meshheading:10611481-Antibodies,
pubmed-meshheading:10611481-Cyclic AMP,
pubmed-meshheading:10611481-Cyclic GMP,
pubmed-meshheading:10611481-Cyclic Nucleotide Phosphodiesterases, Type 5,
pubmed-meshheading:10611481-Cystic Fibrosis Transmembrane Conductance Regulator,
pubmed-meshheading:10611481-Humans,
pubmed-meshheading:10611481-Isoproterenol,
pubmed-meshheading:10611481-Mucins,
pubmed-meshheading:10611481-Purinones,
pubmed-meshheading:10611481-Pyridazines,
pubmed-meshheading:10611481-Pyridines,
pubmed-meshheading:10611481-Rats,
pubmed-meshheading:10611481-Rolipram,
pubmed-meshheading:10611481-Submandibular Gland
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pubmed:year |
1999
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pubmed:articleTitle |
A cyclic nucleotide PDE5 inhibitor corrects defective mucin secretion in submandibular cells containing antibody directed against the cystic fibrosis transmembrane conductance regulator protein.
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pubmed:affiliation |
Department of Medical Biochemistry, University of Wales College of Medicine, Heath Park, Cardiff, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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