Source:http://linkedlifedata.com/resource/pubmed/id/10609670
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2000-1-18
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| pubmed:abstractText |
Carriers of the apolipoprotein E (APOE) epsilon4 allele show significantly higher risk of Alzheimer disease (AD). The aim of this present study was to test the hypothesis that a significant interaction exists between APOE genotype and gender on AD. Interactions of epsilon4 by gender, although indicated in the literature, require further verification. A total of 195 past or current control or AD participants in an ongoing longitudinal study of aging and dementia were genotyped. All subjects were at least 60 years old; demented subjects met clinical or pathologic criteria for late-onset AD. Logistic regression analysis and proportional hazard models were used to evaluate joint effects of APOE and gender. A significant statistical interaction between APOE and gender was shown (p = 0.04) in logistic regression analysis. Women carrying one or more APOE-epsilon4 allele were more likely to develop AD [odds ratio (OR) = 7.8, 95% confidence interval (CI) = 3.2-19. 1]. For men, the presence of the APOE-epsilon4 allele was not associated with a statistically significant increased risk (OR = 1.6, 95% CI = 0.5-5.3). The interaction term in the proportional hazards model neared (p = 0.07) statistical significance, and a similar but reduced gender effect was shown. The analysis suggests that the presence of one or more APOE-epsilon4 allele confers a substantially greater risk of AD to women than to men. These findings in part may account for reports of increased risk of AD faced by women.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0893-0341
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
13
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
216-21
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:10609670-Aged,
pubmed-meshheading:10609670-Aged, 80 and over,
pubmed-meshheading:10609670-Alleles,
pubmed-meshheading:10609670-Alzheimer Disease,
pubmed-meshheading:10609670-Apolipoprotein E4,
pubmed-meshheading:10609670-Apolipoproteins E,
pubmed-meshheading:10609670-Female,
pubmed-meshheading:10609670-Genetic Markers,
pubmed-meshheading:10609670-Genotype,
pubmed-meshheading:10609670-Humans,
pubmed-meshheading:10609670-Logistic Models,
pubmed-meshheading:10609670-Longitudinal Studies,
pubmed-meshheading:10609670-Male,
pubmed-meshheading:10609670-Middle Aged,
pubmed-meshheading:10609670-Proportional Hazards Models,
pubmed-meshheading:10609670-Retrospective Studies,
pubmed-meshheading:10609670-Risk Factors,
pubmed-meshheading:10609670-Sex Factors
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| pubmed:articleTitle |
Evidence for an interaction between apolipoprotein E genotype, gender, and Alzheimer disease.
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| pubmed:affiliation |
Andrus Gerontology Center, University of Southern California, Los Angeles, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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