Source:http://linkedlifedata.com/resource/pubmed/id/10608757
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| rdf:type | |
| lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0019693,
umls-concept:C0032659,
umls-concept:C0034790,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0205374,
umls-concept:C0205390,
umls-concept:C0439828,
umls-concept:C1285572,
umls-concept:C1314763,
umls-concept:C1332714,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1521725,
umls-concept:C1706438,
umls-concept:C1880022,
umls-concept:C2698600
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| pubmed:issue |
1
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| pubmed:dateCreated |
2000-3-3
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| pubmed:abstractText |
T cell receptor (TCR) repertoire perturbations are commonly detected in CD8+ T cells during adult primary human immunodeficiency virus (HIV) infection and have been associated with HIV-specific cytotoxic T cell responses. By use of flow cytometry, transient high-level TCR beta-chain variable region-specific expansions of CD4+ and CD8+ T cells were observed more frequently in HIV-infected children than in children exposed to HIV who remained uninfected. TCR beta-chain diversity analysis and diversity-specific polymerase chain reaction were used to study the clonality of expanded CD4+ and CD8+ subsets. In CD8+ T cells, structural features of the complement-determining regions 3 were altered during the course of the expansion, and persistent TCR clonotypes were observed, consistent with antigen-driven selection. In contrast, TCR beta-chain variable region-specific expansions without clonotypic overrepresentation or persistence were observed in CD4+ T cells, possibly related to HIV-specific helper T cell responses or to the progressive destruction of the CD4+ cell compartment.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0022-1899
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
181
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
107-20
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:10608757-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10608757-CD8-Positive T-Lymphocytes,
pubmed-meshheading:10608757-Child, Preschool,
pubmed-meshheading:10608757-Genes, T-Cell Receptor beta,
pubmed-meshheading:10608757-HIV Infections,
pubmed-meshheading:10608757-HIV-1,
pubmed-meshheading:10608757-Humans,
pubmed-meshheading:10608757-Infant,
pubmed-meshheading:10608757-Infant, Newborn,
pubmed-meshheading:10608757-Infectious Disease Transmission, Vertical,
pubmed-meshheading:10608757-Longitudinal Studies,
pubmed-meshheading:10608757-Lymphocyte Activation,
pubmed-meshheading:10608757-Phenotype,
pubmed-meshheading:10608757-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:10608757-T-Lymphocyte Subsets,
pubmed-meshheading:10608757-T-Lymphocytes
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Transient T cell receptor beta-chain variable region-specific expansions of CD4+ and CD8+ T cells during the early phase of pediatric human immunodeficiency virus infection: characterization of expanded cell populations by T cell receptor phenotyping.
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| pubmed:affiliation |
Laboratoire d'Immunologie, Institut de Recherches Cliniques de Montréal, McGill University, Montreal, Canada. hsoudeyns@justine.umontreal.ca
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|