Source:http://linkedlifedata.com/resource/pubmed/id/10607711
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2000-1-31
|
| pubmed:abstractText |
To determine the relative in vivo importance of IL-1 release after allergen challenge to the subsequent endothelial adhesion and recruitment of eosinophils, the authors used ovalbumin sensitization and inhalation challenge to induce airway eosinophilia in IL-1 receptor type 1-deficient and control wild-type mice. Bronchoalveolar lavage (BAL) eosinophil recruitment in IL-1 receptor type 1-deficient mice challenged with ovalbumin (24.3% +/- 6.3% BAL eosinophils) was significantly reduced compared with wild-type mice (63.7% +/- 2.5% BAL eosinophils). To determine whether the inhibition of eosinophil adhesion to vascular endothelium contributed to the inhibition of eosinophil recruitment in IL-1 receptor type 1-deficient mice, the authors used intravital microscopy to visualize the rolling and firm adhesion of fluorescence-labeled mouse eosinophils in the microvasculature of the allergen-challenged mouse mesentery. Eosinophil rolling, eosinophil firm adhesion to endothelium, and transmigration across endothelium (peritoneal eosinophils) were significantly inhibited in allergen-challenged IL-1 receptor type 1-deficient mice compared with wild-type mice. Overall, these studies demonstrate that cytokines such as IL-1, released after allergen challenge, are important in the induction of endothelial cell adhesiveness, a prerequisite for the recruitment of circulating eosinophils. (Blood. 2000;95:263-269)
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0006-4971
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
95
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
263-9
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:10607711-Allergens,
pubmed-meshheading:10607711-Animals,
pubmed-meshheading:10607711-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:10607711-Cell Adhesion,
pubmed-meshheading:10607711-Endothelium, Vascular,
pubmed-meshheading:10607711-Eosinophils,
pubmed-meshheading:10607711-Female,
pubmed-meshheading:10607711-Hypersensitivity, Immediate,
pubmed-meshheading:10607711-Inflammation,
pubmed-meshheading:10607711-Interleukin-5,
pubmed-meshheading:10607711-Lung,
pubmed-meshheading:10607711-Mice,
pubmed-meshheading:10607711-Mice, Inbred C57BL,
pubmed-meshheading:10607711-Mice, Inbred Strains,
pubmed-meshheading:10607711-Mice, Knockout,
pubmed-meshheading:10607711-Mice, Transgenic,
pubmed-meshheading:10607711-Pollen,
pubmed-meshheading:10607711-Receptors, Interleukin-1,
pubmed-meshheading:10607711-Skin Tests
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Inhibition of eosinophilic inflammation in allergen-challenged, IL-1 receptor type 1-deficient mice is associated with reduced eosinophil rolling and adhesion on vascular endothelium.
|
| pubmed:affiliation |
Department of Medicine, University of California, San Diego, La Jolla 92093-0635, USA. dbroide@ucsd.edu
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|