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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-2-7
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pubmed:abstractText |
Immunoglobulin gene rearrangements in patients treated with BMT have restricted repertoire diversity. Clonal variability remains low for 3 months and reconstitution of the humoral immune system appears to follow a wave-like pattern. In the present study we analysed serum IgM and IgG repertoires in 44 patients from 1 week to 3 years after transplantation. We applied a quantitative immunoblot technique in combination with a newly developed method for estimation of repertoire diversity in complex mixtures of antibodies. Our results demonstrate that 60% of BMT patients have severely reduced diversity in the IgM repertoire during and after the first year post-BMT, compared with healthy controls. In contrast, the majority of patients have a polyclonal IgG repertoire, similar to that of healthy controls. Serum IgM repertoires remain oligoclonal even though the serum concentration of total IgM is within normal range around 6 months post-BMT. During the first years after transplantation IgM as well as IgG repertoires are less diverse in patients receiving a BM graft from a sibling donor compared with those receiving a graft from an HLA-matched unrelated donor. Patients in the latter group show a higher incidence of infections and minor antigen mismatches which may promote the development of a diverse immunoglobulin repertoire post-BMT.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-10464171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-1628122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-2059758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-2186835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-2193017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-2197342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-2665854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-3058579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-3542077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-7579369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-7994052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-8223861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-8290896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-8525515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-8611731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-8634435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-8639897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-8953042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-8953043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-8978315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-9232606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-9247595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-9255622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-9255623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-9267666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-9323210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-9323211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-9354669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10606989-9674856
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
119
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
240-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10606989-Adult,
pubmed-meshheading:10606989-Antibody Diversity,
pubmed-meshheading:10606989-Bone Marrow Transplantation,
pubmed-meshheading:10606989-Case-Control Studies,
pubmed-meshheading:10606989-Graft Survival,
pubmed-meshheading:10606989-Humans,
pubmed-meshheading:10606989-Immunoglobulin G,
pubmed-meshheading:10606989-Immunoglobulin M,
pubmed-meshheading:10606989-Living Donors,
pubmed-meshheading:10606989-Middle Aged,
pubmed-meshheading:10606989-Nuclear Family,
pubmed-meshheading:10606989-Time Factors,
pubmed-meshheading:10606989-Transplantation, Homologous
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pubmed:year |
2000
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pubmed:articleTitle |
Long-term persistence of oligoclonal serum IgM repertoires in patients treated with allogeneic bone marrow transplantation (BMT).
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pubmed:affiliation |
Department of Immunology, Division of Clinical Immunology, Karolinskia Institutet, Hudinge, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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