|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2000-1-19
|
|
pubmed:abstractText |
The role of aromatic hydrocarbon receptor (AhR)-mediated signal transduction pathways was investigated in the regulation of ascorbate synthesis by using Ah-responsive and Ah-unresponsive mouse strains. In vivo 3-methylcholanthrene treatment increased hepatic and plasma ascorbate concentrations only in the Ah-responsive strain. The mRNA level of gulonolactone oxidase and the microsomal ascorbate production from p-nitrophenyl glucuronide, D-glucuronic acid or gulonolactone in the liver of Ah-responsive and Ah-unresponsive mice were compared. In Ah-responsive mice, these parameters were higher originally, and they further increased upon in vivo addition of 3-methylcholanthrene, while in Ah-unresponsive mice the treatment was not effective. These results suggest that the transcription of gulonolactone oxidase gene is regulated by an Ah receptor-dependent signal transduction pathway.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-nitrophenylglucuronide,
http://linkedlifedata.com/resource/pubmed/chemical/Ascorbic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP1A1,
http://linkedlifedata.com/resource/pubmed/chemical/Glucaric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronates,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronides,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronosyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/L-Gulonolactone Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Methylcholanthrene,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Aryl Hydrocarbon,
http://linkedlifedata.com/resource/pubmed/chemical/Sugar Alcohol Dehydrogenases,
http://linkedlifedata.com/resource/pubmed/chemical/UDP-glucuronosyltransferase, UGT1A6,
http://linkedlifedata.com/resource/pubmed/chemical/saccharolactone
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0014-5793
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
17
|
|
pubmed:volume |
463
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
345-9
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:10606751-Animals,
pubmed-meshheading:10606751-Ascorbic Acid,
pubmed-meshheading:10606751-Cytochrome P-450 CYP1A1,
pubmed-meshheading:10606751-Glucaric Acid,
pubmed-meshheading:10606751-Glucuronates,
pubmed-meshheading:10606751-Glucuronic Acid,
pubmed-meshheading:10606751-Glucuronides,
pubmed-meshheading:10606751-Glucuronosyltransferase,
pubmed-meshheading:10606751-L-Gulonolactone Oxidase,
pubmed-meshheading:10606751-Male,
pubmed-meshheading:10606751-Methylcholanthrene,
pubmed-meshheading:10606751-Mice,
pubmed-meshheading:10606751-Mice, Inbred Strains,
pubmed-meshheading:10606751-Microsomes, Liver,
pubmed-meshheading:10606751-RNA, Messenger,
pubmed-meshheading:10606751-Receptors, Aryl Hydrocarbon,
pubmed-meshheading:10606751-Signal Transduction,
pubmed-meshheading:10606751-Sugar Alcohol Dehydrogenases,
pubmed-meshheading:10606751-Time Factors
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Different induction of gulonolactone oxidase in aromatic hydrocarbon-responsive or -unresponsive mouse strains.
|
|
pubmed:affiliation |
Department of Medical Chemistry, Semmelweis University of Medicine, H-1444, Budapest, Hungary.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
