Source:http://linkedlifedata.com/resource/pubmed/id/10606164
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2000-1-18
|
| pubmed:abstractText |
The (NZW x BXSB)F1 (W/BF1) mouse is known as an autoimmune-prone strain which develops lupus nephritis, thrombocytopenia due to platelet-specific autoantibodies, leukocytosis, and myocardial infarction. In this experiment, we investigated the age-dependent abnormalities of the hematopoietic stem cells (HSCs) and hematopoiesis in this mouse. White blood cell counts (especially Mac-1- or Gr-1-positive cells) in the peripheral blood of 12-week-old W/BF1 mice increased in comparison with those of four-week-old W/BF1 or normal mice. To investigate whether the abnormal hematopoiesis can be attributed to the HSCs of W/BF1 mice, colony-forming unit in spleen (CFU-S) and colony-forming unit in culture (CFU-C) assays were performed. Day 12 CFU-S counts of 12-week-old W/BF1 mice significantly increased in comparison with those of four-week-old W/BF1 mice or normal mice. In the CFU-C assay, CFU-GEMM and CFU-GM counts in 12-week-old W/BF1 mice increased in comparison with those of four-week-old W/BF1 or control mice. The bone marrow cells (BMCs) from 12-week-old W/BF1 mice showed a high level of G-CSF and a low level of GM-CSF in mRNA expression. To examine the effect of HSCs from 12-week-old W/BF1 mice on the onset of autoimmune diseases and the abnormal hematopoiesis, T- and B-cell-depleted BMCs of four-week-old or 12-week-old W/BF1 mice were transplanted to C3H mice. Recipient C3H mice that had received the BMCs from 12-week-old W/BF1 mice showed an earlier onset of autoimmune diseases and a shorter survival rate than those that had received the BMCs from four-week-old W/BF1 mice. These data suggest that the HSCs from 12-week-old W/BF1 mice showing the symptoms of autoimmune diseases have the capacity to induce autoimmune diseases earlier than the HSCs from four-week-old W/BF1 mice.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte Colony-Stimulating...,
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte-Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Colony-Stimulating Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage-1 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1066-5099
|
| pubmed:author |
pubmed-author:AdachiYY,
pubmed-author:AmosLL,
pubmed-author:GenbaHH,
pubmed-author:HishaHH,
pubmed-author:HorioTT,
pubmed-author:IkebukuroKK,
pubmed-author:IkeharaSS,
pubmed-author:InabaMM,
pubmed-author:KawamuraMM,
pubmed-author:MiyashimaSS,
pubmed-author:OyaizuHH,
pubmed-author:SugiharaAA,
pubmed-author:SugiuraKK,
pubmed-author:TaketaniSS
|
| pubmed:issnType |
Print
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
357-65
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:10606164-Age of Onset,
pubmed-meshheading:10606164-Aging,
pubmed-meshheading:10606164-Animals,
pubmed-meshheading:10606164-Disease Models, Animal,
pubmed-meshheading:10606164-Gene Expression,
pubmed-meshheading:10606164-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:10606164-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:10606164-Hematopoiesis,
pubmed-meshheading:10606164-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:10606164-Hematopoietic Stem Cells,
pubmed-meshheading:10606164-Leukocyte Count,
pubmed-meshheading:10606164-Leukocytosis,
pubmed-meshheading:10606164-Lupus Nephritis,
pubmed-meshheading:10606164-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:10606164-Macrophage-1 Antigen,
pubmed-meshheading:10606164-Male,
pubmed-meshheading:10606164-Mice,
pubmed-meshheading:10606164-Mice, Inbred BALB C,
pubmed-meshheading:10606164-Mice, Inbred C3H,
pubmed-meshheading:10606164-Mice, Inbred NZB,
pubmed-meshheading:10606164-Platelet Count,
pubmed-meshheading:10606164-RNA, Messenger,
pubmed-meshheading:10606164-Survival Analysis,
pubmed-meshheading:10606164-Thrombocytopenia
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Age-dependent abnormalities of hematopoietic stem cells in (NZW x BXSB)F1 mice.
|
| pubmed:affiliation |
First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan.
|
| pubmed:publicationType |
Journal Article
|