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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-1-19
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pubmed:abstractText |
OBF-1 is a B cell-restricted transcriptional coactivator that is recruited to octamer-containing promoters by interacting with the POU domain of Oct-1 or Oct-2. We have shown earlier that mice lacking OBF-1 were dramatically impaired in their ability to mount humoral immune responses and did not develop germinal centers in the spleen; however, they had a largely normal B cell development in the bone marrow. In this study, we demonstrate that OBF-1-deficient mice also have an early defect in B cell development and show that OBF-1-/- immature B cells are greatly impaired at the transition from the bone marrow to the spleen. In addition, when the OBF-1 mutation is combined to a mutation in the gene encoding Bruton's tyrosine kinase, a striking phenotype is observed. These double-deficient animals lack peripheral B cells and have virtually no serum Igs, thus closely resembling human X chromosome-linked agammaglobulinemia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
164
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
18-22
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:10604987-Agammaglobulinemia,
pubmed-meshheading:10604987-Animals,
pubmed-meshheading:10604987-B-Lymphocytes,
pubmed-meshheading:10604987-Cell Differentiation,
pubmed-meshheading:10604987-Female,
pubmed-meshheading:10604987-Gene Expression Regulation,
pubmed-meshheading:10604987-Gene Expression Regulation, Developmental,
pubmed-meshheading:10604987-Genes, Immunoglobulin,
pubmed-meshheading:10604987-Genetic Linkage,
pubmed-meshheading:10604987-Humans,
pubmed-meshheading:10604987-Immunoglobulins,
pubmed-meshheading:10604987-Lymphoid Tissue,
pubmed-meshheading:10604987-Lymphopenia,
pubmed-meshheading:10604987-Male,
pubmed-meshheading:10604987-Mice,
pubmed-meshheading:10604987-Mice, Inbred C57BL,
pubmed-meshheading:10604987-Mice, Inbred CBA,
pubmed-meshheading:10604987-Mice, Knockout,
pubmed-meshheading:10604987-Multigene Family,
pubmed-meshheading:10604987-Phenotype,
pubmed-meshheading:10604987-Protein-Tyrosine Kinases,
pubmed-meshheading:10604987-Trans-Activators,
pubmed-meshheading:10604987-X Chromosome
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pubmed:year |
2000
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pubmed:articleTitle |
Cutting edge: lack of peripheral B cells and severe agammaglobulinemia in mice simultaneously lacking Bruton's tyrosine kinase and the B cell-specific transcriptional coactivator OBF-1.
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pubmed:affiliation |
Friedrich Miescher-Institute, Basel, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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