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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
25
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pubmed:dateCreated |
2000-1-13
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pubmed:abstractText |
Cardiopulmonary bypass (CPB) induces a systemic inflammatory response that causes substantial clinical morbidity. Activation of complement during CPB contributes significantly to this inflammatory process. We examined the capability of a novel therapeutic complement inhibitor to prevent pathological complement activation and tissue injury in patients undergoing CPB.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0009-7322
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pubmed:author |
pubmed-author:AlfordBB,
pubmed-author:ArankiSS,
pubmed-author:CollardC DCD,
pubmed-author:DewarMM,
pubmed-author:ElefteriadesJJ,
pubmed-author:FitchJ CJC,
pubmed-author:HinesRR,
pubmed-author:KopfGG,
pubmed-author:KrakerPP,
pubmed-author:LORR,
pubmed-author:MatisLL,
pubmed-author:O'HaraRR,
pubmed-author:RinderCC,
pubmed-author:RinderHH,
pubmed-author:RollinsSS,
pubmed-author:ShawRR,
pubmed-author:ShernanS KSK,
pubmed-author:SmithBB,
pubmed-author:StahlGG
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pubmed:issnType |
Print
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pubmed:volume |
100
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2499-506
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:10604887-Antibodies, Monoclonal,
pubmed-meshheading:10604887-Antibodies, Monoclonal, Humanized,
pubmed-meshheading:10604887-Blood Loss, Surgical,
pubmed-meshheading:10604887-Cardiopulmonary Bypass,
pubmed-meshheading:10604887-Cognition Disorders,
pubmed-meshheading:10604887-Complement Activation,
pubmed-meshheading:10604887-Complement C5,
pubmed-meshheading:10604887-Complement Membrane Attack Complex,
pubmed-meshheading:10604887-Coronary Artery Bypass,
pubmed-meshheading:10604887-Coronary Disease,
pubmed-meshheading:10604887-Creatine Kinase,
pubmed-meshheading:10604887-Humans,
pubmed-meshheading:10604887-Inflammation,
pubmed-meshheading:10604887-Isoenzymes,
pubmed-meshheading:10604887-Middle Aged,
pubmed-meshheading:10604887-Myocardial Reperfusion Injury,
pubmed-meshheading:10604887-Postoperative Complications,
pubmed-meshheading:10604887-Prospective Studies,
pubmed-meshheading:10604887-Psychological Tests,
pubmed-meshheading:10604887-Single-Chain Antibodies
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pubmed:articleTitle |
Pharmacology and biological efficacy of a recombinant, humanized, single-chain antibody C5 complement inhibitor in patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass.
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pubmed:affiliation |
Department of Anesthesiology, Yale University, New Haven, CT, USA. jfitch@bcm.tmc.edu
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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