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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-1-11
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pubmed:abstractText |
Streptomyces griseus strains isolated from indoor dust have been shown to synthesize valinomycin. In this report, we show that human peripheral blood lymphocytes treated with small doses (30 ng ml(-1)) of pure valinomycin or high-pressure liquid chromatography-pure valinomycin from S. griseus quickly show mitochondrial swelling and reduced NK cell activity. Larger doses (>100 ng/ml(-1)) induced NK cell apoptosis within 2 days. Within 2 h, the toxin at 100 ng ml(-1) dramatically inhibited interleukin-15 (IL-15)- and IL-18-induced granulocyte-macrophage colony-stimulating factor and gamma interferon (IFN-gamma) production by NK cells. However, IFN-gamma production induced by a combination of IL-15 and IL-18 was somewhat less sensitive to valinomycin, suggesting a protective effect of the cytokine combination against valinomycin. Thus, valinomycin in very small doses may profoundly alter the immune response by reducing NK cell cytotoxicity and cytokine production.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-10200467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-10212408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-10429194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-1326477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-1915662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-2140788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-2265240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-2384670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-2450162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-2683611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-4512889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-7477296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-7487000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-8119494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-8375466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-8541445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-8608497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-8666798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-8675621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-8766574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-9023919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-9039782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-9062351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-9190109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-9208838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-9284124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-9431461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-9529155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-9637519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-9835560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10603383-9846488
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
165-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10603383-Air Microbiology,
pubmed-meshheading:10603383-Anti-Bacterial Agents,
pubmed-meshheading:10603383-Apoptosis,
pubmed-meshheading:10603383-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:10603383-Humans,
pubmed-meshheading:10603383-Immunosuppressive Agents,
pubmed-meshheading:10603383-Interferon-gamma,
pubmed-meshheading:10603383-Interleukin-15,
pubmed-meshheading:10603383-Interleukin-18,
pubmed-meshheading:10603383-Killer Cells, Natural,
pubmed-meshheading:10603383-Microscopy, Electron,
pubmed-meshheading:10603383-Microscopy, Electron, Scanning,
pubmed-meshheading:10603383-Mitochondrial Swelling,
pubmed-meshheading:10603383-Streptomyces,
pubmed-meshheading:10603383-Valinomycin
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pubmed:year |
2000
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pubmed:articleTitle |
Inhibition of human NK cell function by valinomycin, a toxin from Streptomyces griseus in indoor air.
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pubmed:affiliation |
Department of Pathology, Haartman Institute, FIN-00014 University of Helsinki, Finland. auli.paananen@helsinki.fi
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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