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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2000-1-6
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pubmed:abstractText |
The AML1 and CBFbeta subunits of core binding factor (CBF) are involved in several chromosomal abnormalities frequently associated with acute leukemias. As a result, the CBFbeta-SMMHC, AML1-ETO and AML1-MDS1/EVI1 fusion proteins are expressed in subsets of acute myeloid leukemia, and TEL-AML1 is expressed in B-lineage acute lymphocytic leukemia. These CBF oncoproteins likely contribute to leukemogenesis in part by inhibiting endogenous CBF. As a result they are expected to inhibit differentiation and perhaps apoptosis. In addition, the domains unique to each fusion protein may also contribute to leukemogenesis via unique mechanisms.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Core Binding Factor Alpha 2 Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MECOM protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RUNX1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RUNX1T1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor AP-2,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0887-6924
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1932-42
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pubmed:dateRevised |
2011-9-28
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pubmed:meshHeading |
pubmed-meshheading:10602413-Apoptosis,
pubmed-meshheading:10602413-Core Binding Factor Alpha 2 Subunit,
pubmed-meshheading:10602413-DNA-Binding Proteins,
pubmed-meshheading:10602413-Humans,
pubmed-meshheading:10602413-Leukemia,
pubmed-meshheading:10602413-Neoplasm Proteins,
pubmed-meshheading:10602413-Oncogene Proteins, Fusion,
pubmed-meshheading:10602413-Proteins,
pubmed-meshheading:10602413-Proto-Oncogene Proteins,
pubmed-meshheading:10602413-Proto-Oncogenes,
pubmed-meshheading:10602413-Transcription Factor AP-2,
pubmed-meshheading:10602413-Transcription Factors
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pubmed:year |
1999
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pubmed:articleTitle |
Leukemogenesis by CBF oncoproteins.
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pubmed:affiliation |
Division of Pediatric Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Research Support, Non-U.S. Gov't
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