Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2000-2-15
pubmed:abstractText
AIDS encephalitis is a frequent consequence of CNS HIV infection, especially in children. One of its many characteristics is a leukocyte infiltrate that is believed to contribute to the production of cytokines, chemokines and neurotoxic factors resulting in CNS damage. Entry of such leukocytes into the CNS is mediated in part by the expression of adhesion molecules by blood - brain barrier (BBB) endothelial cells. Expression of these proteins by astrocytes, the other main component of the BBB, also serves to target leukocytes to the CNS parenchyma. We now demonstrate that HIV-1-derived Tat, a soluble protein secreted by infected cells, induced astrocyte VCAM-1 and ICAM-1 expression in a dose- and time-dependent manner. The functional role of Tat in monocyte binding in vitro was also demonstrated. These data suggest that the presence of extracellular Tat may be a significant factor in the trafficking of HIV-infected and inflammatory cells into the CNS via its effect on adhesion molecule expression by astrocytes.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1355-0284
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
678-84
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:10602408-Astrocytes, pubmed-meshheading:10602408-Blotting, Northern, pubmed-meshheading:10602408-Cell Adhesion, pubmed-meshheading:10602408-Cells, Cultured, pubmed-meshheading:10602408-Culture Media, pubmed-meshheading:10602408-Dose-Response Relationship, Drug, pubmed-meshheading:10602408-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:10602408-Gene Products, tat, pubmed-meshheading:10602408-HIV Antibodies, pubmed-meshheading:10602408-HIV-1, pubmed-meshheading:10602408-Humans, pubmed-meshheading:10602408-Intercellular Adhesion Molecule-1, pubmed-meshheading:10602408-Monocytes, pubmed-meshheading:10602408-RNA, Messenger, pubmed-meshheading:10602408-U937 Cells, pubmed-meshheading:10602408-Vascular Cell Adhesion Molecule-1, pubmed-meshheading:10602408-tat Gene Products, Human Immunodeficiency Virus
pubmed:year
1999
pubmed:articleTitle
Human immunodeficiency virus type 1 TAT protein induces adhesion molecule expression in astrocytes.
pubmed:affiliation
Department of Pathology, Albert Einstein College of Medicine Bronx, New York, NY 10461, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.