Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2000-1-21
pubmed:abstractText
To assess the cancer risk of monoclonal gammopathy of undetermined significance (MGUS) we identified 1229 cases of MGUS in the period 1978 to 1993. Data on cancer occurrence in the MGUS cohort were obtained from the Danish Cancer Registry. The expected numbers of cancer cases were calculated from age-, sex-, county-, and period-specific cancer incidence rates. In the MGUS cohort 64 new cancers with a known association with M-components were diagnosed versus 5.0 expected giving a standardized incidence ratio (SIR) of 12.9 (95% confidence interval, 9.9-16.5). The relative risks of developing multiple myeloma (SIR 34.3), Waldenström's macroglobulinemia (SIR 63.8), and non-Hodgkin's lymphoma (SIR 5.9) were significantly increased and independent of time passed from detection of the M-component. The relative risk of chronic lymphocytic leukemia was not significantly increased, SIR 2.7 (0.5-7. 7). Among cancer sites without known association with M-components 141 cases were observed versus 94.6 expected giving a SIR of 1.5 (1. 3-1.8). This enhanced risk was seen for several non-hematological cancer sites but for most cancer sites the risk was dependent on time passed from detection of the M-component, indicating a bias rather than a causal role of MGUS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0361-8609
pubmed:author
pubmed:copyrightInfo
Copyright 2000 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10602159-Adolescent, pubmed-meshheading:10602159-Adult, pubmed-meshheading:10602159-Aged, pubmed-meshheading:10602159-Aged, 80 and over, pubmed-meshheading:10602159-Child, pubmed-meshheading:10602159-Cohort Studies, pubmed-meshheading:10602159-Female, pubmed-meshheading:10602159-Humans, pubmed-meshheading:10602159-Immunoglobulin A, pubmed-meshheading:10602159-Immunoglobulin G, pubmed-meshheading:10602159-Immunoglobulin Light Chains, pubmed-meshheading:10602159-Immunoglobulin M, pubmed-meshheading:10602159-Lymphoma, Non-Hodgkin, pubmed-meshheading:10602159-Male, pubmed-meshheading:10602159-Middle Aged, pubmed-meshheading:10602159-Multiple Myeloma, pubmed-meshheading:10602159-Neoplasms, pubmed-meshheading:10602159-Paraproteinemias, pubmed-meshheading:10602159-Risk Factors, pubmed-meshheading:10602159-Waldenstrom Macroglobulinemia
pubmed:year
2000
pubmed:articleTitle
Cancer risk in patients with monoclonal gammopathy of undetermined significance.
pubmed:affiliation
Department of Hematology B, Aalborg Hospital, Aalborg, Denmark. henrik.gregersen@dadlnet.dk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't