|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1-2
|
|
pubmed:dateCreated |
2000-2-3
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Pax4 is a paired-box transcription factor that plays an important role in the development of pancreatic beta-cells. Two Pax4 cDNAs were isolated from a rat insulinoma library. One contained the full-length sequence of Pax4. The other, termed Pax4c, was identical to Pax4 but lacked the sequences encoding 117 amino acids at the COOH-terminus. Pax4 was found to inhibit the human insulin promoter through a sequence element, the C2 box, located at -253 to -244, and the islet amyloid polypeptide promoter through a sequence element located downstream of -138. The inhibitory activity of Pax4 was mapped to separate regions of the protein between amino acids 2-230 and 231-349.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Islet Amyloid Polypeptide,
http://linkedlifedata.com/resource/pubmed/chemical/PAX4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Paired Box Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Pax4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Pax4 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0014-5793
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
10
|
|
pubmed:volume |
463
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
53-7
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:10601637-Amyloid,
pubmed-meshheading:10601637-Animals,
pubmed-meshheading:10601637-Cell Line,
pubmed-meshheading:10601637-Cloning, Molecular,
pubmed-meshheading:10601637-DNA, Complementary,
pubmed-meshheading:10601637-Gene Library,
pubmed-meshheading:10601637-Homeodomain Proteins,
pubmed-meshheading:10601637-Humans,
pubmed-meshheading:10601637-Insulin Antagonists,
pubmed-meshheading:10601637-Islet Amyloid Polypeptide,
pubmed-meshheading:10601637-Islets of Langerhans,
pubmed-meshheading:10601637-Mice,
pubmed-meshheading:10601637-Paired Box Transcription Factors,
pubmed-meshheading:10601637-Plasmids,
pubmed-meshheading:10601637-Promoter Regions, Genetic,
pubmed-meshheading:10601637-Protein Biosynthesis,
pubmed-meshheading:10601637-Protein Isoforms,
pubmed-meshheading:10601637-Rats,
pubmed-meshheading:10601637-Transcription Factors,
pubmed-meshheading:10601637-Transfection
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Inhibitory effect of pax4 on the human insulin and islet amyloid polypeptide (IAPP) promoters.
|
|
pubmed:affiliation |
Department of Molecular and Cell Biology, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, UK.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
