Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1976-2-19
pubmed:abstractText
Microvariant RNA, a small self-replicating molecule (114 nucleotides long), has been isolated from Qbeta replicase reactions incubated in the absence of exogenous template. Its complete nucleotide sequence has been determined. Comparison with MDV-1 RNA, a somewhat larger endogenous Qbeta replicase product (220 nucleotides long) that had previously been characterized, revealed no significant sequence similarity. Since Qbeta replicase can mediate the synthesis of both of these disparate RNA molecules, primary sequence cannot be the sole determining factor in the processes of enzyme recognition and replication. This implies that the key is to be found in the secondary or tertiary structures. The availability of two different replicating molecules of defined sequence should aid in identifying these critical structural features.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1060104-1054493, http://linkedlifedata.com/resource/pubmed/commentcorrection/1060104-4449129, http://linkedlifedata.com/resource/pubmed/commentcorrection/1060104-4507621, http://linkedlifedata.com/resource/pubmed/commentcorrection/1060104-4519026, http://linkedlifedata.com/resource/pubmed/commentcorrection/1060104-4706684, http://linkedlifedata.com/resource/pubmed/commentcorrection/1060104-4904405, http://linkedlifedata.com/resource/pubmed/commentcorrection/1060104-4936434, http://linkedlifedata.com/resource/pubmed/commentcorrection/1060104-5217445, http://linkedlifedata.com/resource/pubmed/commentcorrection/1060104-5217468, http://linkedlifedata.com/resource/pubmed/commentcorrection/1060104-5231602, http://linkedlifedata.com/resource/pubmed/commentcorrection/1060104-5243928, http://linkedlifedata.com/resource/pubmed/commentcorrection/1060104-5259764, http://linkedlifedata.com/resource/pubmed/commentcorrection/1060104-5325727, http://linkedlifedata.com/resource/pubmed/commentcorrection/1060104-5328121, http://linkedlifedata.com/resource/pubmed/commentcorrection/1060104-5492605, http://linkedlifedata.com/resource/pubmed/commentcorrection/1060104-5835788
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4252-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Nucleotide sequence of microvariant RNA: another small replicating molecule.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.