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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2000-1-27
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pubmed:abstractText |
Although retinoic acid receptor alpha (RARalpha) agonists induce the maturation of t(15;17) acute promyelocytic leukemia (APL) cells, drug treatment also selects leukemic blasts expressing PML-RARalpha fusion proteins with mutated ligand-binding domains that no longer respond to all-trans retinoic acid (ATRA). Here we report a novel RARalpha-independent signaling pathway that induces maturation of both ATRA-sensitive and ATRA-resistant APL NB4 cells, and does not invoke the ligand-induced alteration of PML-RARalpha signaling, stability or compartmentalization. This response involves a cross-talk between RXR agonists and protein kinase A signaling. Our results indicate the existence of a separate RXR-dependent maturation pathway that can be activated in the absence of known ligands for RXR heterodimerization partners.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzoates,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Retinoic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoid X Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoids,
http://linkedlifedata.com/resource/pubmed/chemical/SR 11237,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tretinoin,
http://linkedlifedata.com/resource/pubmed/chemical/promyelocytic leukemia-retinoic...,
http://linkedlifedata.com/resource/pubmed/chemical/retinoic acid receptor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/retinoic acid receptor beta
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7011-8
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pubmed:dateRevised |
2008-11-20
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pubmed:meshHeading |
pubmed-meshheading:10601023-Amino Acid Sequence,
pubmed-meshheading:10601023-Base Sequence,
pubmed-meshheading:10601023-Benzoates,
pubmed-meshheading:10601023-Blast Crisis,
pubmed-meshheading:10601023-Chromosomes, Human, Pair 15,
pubmed-meshheading:10601023-Chromosomes, Human, Pair 17,
pubmed-meshheading:10601023-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:10601023-Dimerization,
pubmed-meshheading:10601023-Humans,
pubmed-meshheading:10601023-Leukemia, Promyelocytic, Acute,
pubmed-meshheading:10601023-Neoplasm Proteins,
pubmed-meshheading:10601023-Oncogene Proteins, Fusion,
pubmed-meshheading:10601023-Receptor Cross-Talk,
pubmed-meshheading:10601023-Receptors, Retinoic Acid,
pubmed-meshheading:10601023-Recombinant Fusion Proteins,
pubmed-meshheading:10601023-Retinoid X Receptors,
pubmed-meshheading:10601023-Retinoids,
pubmed-meshheading:10601023-Signal Transduction,
pubmed-meshheading:10601023-Transcription Factors,
pubmed-meshheading:10601023-Translocation, Genetic,
pubmed-meshheading:10601023-Tretinoin
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pubmed:year |
1999
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pubmed:articleTitle |
RAR-independent RXR signaling induces t(15;17) leukemia cell maturation.
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pubmed:affiliation |
INSERM U496, Centre G.Hayem, Hôpital Saint-Louis, 1, Avenue Claude Vellefaux, 75010 Paris.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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