| pubmed-article:10600750 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10600750 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:10600750 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:10600750 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:10600750 | lifeskim:mentions | umls-concept:C0056695 | lld:lifeskim |
| pubmed-article:10600750 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:10600750 | lifeskim:mentions | umls-concept:C0680727 | lld:lifeskim |
| pubmed-article:10600750 | pubmed:issue | 5448 | lld:pubmed |
| pubmed-article:10600750 | pubmed:dateCreated | 2000-1-10 | lld:pubmed |
| pubmed-article:10600750 | pubmed:abstractText | Nerve growth factor (NGF) and other neurotrophins support survival of neurons through processes that are incompletely understood. The transcription factor CREB is a critical mediator of NGF-dependent gene expression, but whether CREB family transcription factors regulate expression of genes that contribute to NGF-dependent survival of sympathetic neurons is unknown. CREB-mediated gene expression was both necessary for NGF-dependent survival and sufficient on its own to promote survival of sympathetic neurons. Moreover, expression of Bcl-2 was activated by NGF and other neurotrophins by a CREB-dependent transcriptional mechanism. Overexpression of Bcl-2 reduced the death-promoting effects of CREB inhibition. Together, these data support a model in which neurotrophins promote survival of neurons, in part through a mechanism involving CREB family transcription factor-dependent expression of genes encoding prosurvival factors. | lld:pubmed |
| pubmed-article:10600750 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10600750 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10600750 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10600750 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10600750 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10600750 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10600750 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10600750 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:10600750 | pubmed:author | pubmed-author:RiccioAA | lld:pubmed |
| pubmed-article:10600750 | pubmed:author | pubmed-author:AhnSS | lld:pubmed |
| pubmed-article:10600750 | pubmed:author | pubmed-author:DavenportC... | lld:pubmed |
| pubmed-article:10600750 | pubmed:author | pubmed-author:GintyD DDD | lld:pubmed |
| pubmed-article:10600750 | pubmed:author | pubmed-author:BlendyJ AJA | lld:pubmed |
| pubmed-article:10600750 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10600750 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:10600750 | pubmed:volume | 286 | lld:pubmed |
| pubmed-article:10600750 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10600750 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10600750 | pubmed:pagination | 2358-61 | lld:pubmed |
| pubmed-article:10600750 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:10600750 | pubmed:meshHeading | pubmed-meshheading:10600750... | lld:pubmed |
| pubmed-article:10600750 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10600750 | pubmed:articleTitle | Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. | lld:pubmed |
| pubmed-article:10600750 | pubmed:affiliation | Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205-2185, USA. | lld:pubmed |
| pubmed-article:10600750 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10600750 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10600750 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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