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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5448
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pubmed:dateCreated |
2000-1-10
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pubmed:abstractText |
Nerve growth factor (NGF) and other neurotrophins support survival of neurons through processes that are incompletely understood. The transcription factor CREB is a critical mediator of NGF-dependent gene expression, but whether CREB family transcription factors regulate expression of genes that contribute to NGF-dependent survival of sympathetic neurons is unknown. CREB-mediated gene expression was both necessary for NGF-dependent survival and sufficient on its own to promote survival of sympathetic neurons. Moreover, expression of Bcl-2 was activated by NGF and other neurotrophins by a CREB-dependent transcriptional mechanism. Overexpression of Bcl-2 reduced the death-promoting effects of CREB inhibition. Together, these data support a model in which neurotrophins promote survival of neurons, in part through a mechanism involving CREB family transcription factor-dependent expression of genes encoding prosurvival factors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
286
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2358-61
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10600750-Animals,
pubmed-meshheading:10600750-Apoptosis,
pubmed-meshheading:10600750-Axons,
pubmed-meshheading:10600750-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:10600750-Cell Nucleus,
pubmed-meshheading:10600750-Cell Survival,
pubmed-meshheading:10600750-Cells, Cultured,
pubmed-meshheading:10600750-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:10600750-Gene Expression Regulation,
pubmed-meshheading:10600750-Genes, bcl-2,
pubmed-meshheading:10600750-Genetic Vectors,
pubmed-meshheading:10600750-Nerve Growth Factor,
pubmed-meshheading:10600750-Neurons,
pubmed-meshheading:10600750-PC12 Cells,
pubmed-meshheading:10600750-Promoter Regions, Genetic,
pubmed-meshheading:10600750-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:10600750-Rats,
pubmed-meshheading:10600750-Recombinant Fusion Proteins,
pubmed-meshheading:10600750-Signal Transduction,
pubmed-meshheading:10600750-Sympathetic Nervous System,
pubmed-meshheading:10600750-Transfection
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pubmed:year |
1999
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pubmed:articleTitle |
Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons.
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pubmed:affiliation |
Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205-2185, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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