Linked Life Data

10600005

Source:http://linkedlifedata.com/resource/pubmed/id/10600005

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2000-1-24
pubmed:abstractText
The specific localization of gamma-aminobutyric acid-transaminase (GABA-t) in the thymus of young and elderly men was studied. Our results show a specific vascular localization of GABA-t in the human thymus, and deal with the amount and distribution of GABA-t and its changes with age. Samples of human thymus were harvested throughout of 12 autopsies in infants (n = 3), as well as young (n = 3), adult (n = 3) and elderly (n = 3) men. Histologic staining of the human thymus was performed with eosin-orange, while histologic staining of nerve fibers was performed with the Bodian method. Histochemical and biochemical demonstration of GABA-t, including protein dosage, was performed by the methods of Van Gelder and Jung, respectively. Finally, quantitative analysis of images was performed. Staining with eosin-orange reveals the micro-anatomical details of the thymic micro-environment. The Bodian method shows the nerve fibers and neurofibrils. Histochemical staining for GABA-t shows an increase of this enzyme with age and a marked localization in the nerve fibers of the thymus in infant, young, adult, and elderly men, as well as specific vascular localization of this enzyme. These biochemical data are in accordance with the histoenzymatic results and confirm all of our previous observations. Finally, quantitative analysis of images performed on slices let us confirm all the morphological changes induced by age. We can conclude that GABA is an inhibitory neurotransmitter of the human thymus, while GABA-t plays an important role in GABA metabolism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0198-8859
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1072-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Occurrence of gamma-aminobutyric acid-transaminase activity in nerve fibers of human thymus.
pubmed:affiliation
Neurologic Clinic, Faculty of Pharmacy, University La Sapienza, Rome, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't