Linked Life Data

10599925

Source:http://linkedlifedata.com/resource/pubmed/id/10599925

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2000-1-24
pubmed:abstractText
We have previously shown that inoculation of Trypanosoma cruzi clone-CL-14 generates efficient protective immunity against virulent T. cruzi and no infection or histopathology per se, indicating that it induces an immune state different from that exhibited by infected animals. To understand the basis of this difference, we screened CL-14-vaccinated mice for T cell abnormalities thought to be involved in the genesis of pathology. Lymphocytes from vaccinated mice present normal proliferative responses to concanavalin A; enhanced responses to T. cruzi antigens; do not show evidence of polyclonal activation (increased blast transformation and lymphocyte numbers) or changes in the density of CD4, CD8 and TCR-beta expression. Also, vaccinated mice display transient expansion of CD8+ lymphocytes expressing activated phenotypes (CD11a(hi) CD45RBlo CD62Llo). In view of the absence of pathology in vaccinated animals, the absence of immunosuppression and the restoration of a resting immune state reinforce the benign nature of this immunization.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0932-0113
pubmed:author
pubmed:issnType
Print
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1012-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Trypanosoma cruzi: lack of T cell abnormalities in mice vaccinated with live trypomastigotes.
pubmed:affiliation
Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, RJ Brazil.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't