Linked Life Data

10599852

Source:http://linkedlifedata.com/resource/pubmed/id/10599852

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
2000-2-28
pubmed:abstractText
The lateral septal nucleus is known to modulate aversive reactions and to receive a strikingly dense substance P (SP) innervation. In the present study, after determining the optimal intracerebroventricular dose (10 pmol) to induce aversive responses, we applied SP directly into the lateral septal nucleus, and quantified anxiogenic responses using the elevated plus-maze (EPM) test. Notably, when placed in the EPM these animals presented clear aversive behaviors expressed either as jumps and bursts of running (darting responses) or freezing. However, we observed an effective increase in the anxiogenic responses evaluated in the EPM test uniquely in the animals that presented freezing. Animals expressing darting responses, in turn, were likely to have a stronger aversive condition, in which anxiogenic-like responses were hindered when measured in the EPM test. Overall, the present results support the idea that SP may have an important modulatory role on anxiogenic responses mediated by the lateral septal nucleus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3399-403
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Anxiogenic-like effect induced by substance P injected into the lateral septal nucleus.
pubmed:affiliation
Department of Pharmacology, CCB, Universidade Federal de Santa Catarina, Florianópolis SC, Brazil.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't