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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2000-1-5
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pubmed:abstractText |
Tumour hypoxia causes resistance to treatment and may promote the development of metastatic disease. The mean fraction of radiobiologically hypoxic cells has been determined for a large number of tumour cell lines, but quantitative information on intertumour heterogeneity in radiobiological hypoxia is sparse, and it is not known whether radiobiological hypoxia is mainly either chronic or acute in nature. The purpose of the work reported here was (1) to determine the fraction of radiobiologically hypoxic cells in individual tumours and (2) to differentiate quantitatively between chronic and acute hypoxia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0955-3002
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1377-93
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:10597912-Acute Disease,
pubmed-meshheading:10597912-Animals,
pubmed-meshheading:10597912-Cell Hypoxia,
pubmed-meshheading:10597912-Cell Separation,
pubmed-meshheading:10597912-Cell Survival,
pubmed-meshheading:10597912-Chronic Disease,
pubmed-meshheading:10597912-Dose-Response Relationship, Radiation,
pubmed-meshheading:10597912-Female,
pubmed-meshheading:10597912-Humans,
pubmed-meshheading:10597912-Immunohistochemistry,
pubmed-meshheading:10597912-Melanoma, Experimental,
pubmed-meshheading:10597912-Mice,
pubmed-meshheading:10597912-Mice, Inbred BALB C,
pubmed-meshheading:10597912-Mice, Nude,
pubmed-meshheading:10597912-Neoplasm Transplantation,
pubmed-meshheading:10597912-Nitroimidazoles,
pubmed-meshheading:10597912-Radiobiology,
pubmed-meshheading:10597912-Staining and Labeling,
pubmed-meshheading:10597912-Transplantation, Heterologous,
pubmed-meshheading:10597912-Tumor Cells, Cultured
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pubmed:year |
1999
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pubmed:articleTitle |
Radiobiological and immunohistochemical assessment of hypoxia in human melanoma xenografts: acute and chronic hypoxia in individual tumours.
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pubmed:affiliation |
Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo. e.k.rofstad@labmed.uio.no
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pubmed:publicationType |
Journal Article
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