| pubmed-article:10597197 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10597197 | lifeskim:mentions | umls-concept:C0031809 | lld:lifeskim |
| pubmed-article:10597197 | lifeskim:mentions | umls-concept:C0014257 | lld:lifeskim |
| pubmed-article:10597197 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:10597197 | lifeskim:mentions | umls-concept:C1801960 | lld:lifeskim |
| pubmed-article:10597197 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:10597197 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:10597197 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10597197 | pubmed:dateCreated | 2000-1-6 | lld:pubmed |
| pubmed-article:10597197 | pubmed:abstractText | To determine whether vascular endothelial growth factor (VEGF)-induced tumor microvascularity is detectable by in vivo NMR imaging, an experimental study was conducted in nude mice. Human breast cancer cells (MCF-7) and MCF-7 cells stably transfected with the cDNA for the VEGF165 isoform (MV165) were grown in nude mice and models were characterized by RT-PCR, Western blotting, ELISA, immunohistochemistry and NMR imaging using a novel synthetic protected graft copolymer (PGC) as a vascular probe. MV165 tumors showed a 1.6-fold higher microvascular density by histology. Both tumors showed identical MR signal intensities on non-contrast and Gd-DTPA enhanced images. PGC enhanced MR imaging of tumoral vascular volume fraction (VVF), however, revealed significant differences between the 2 tumor types (MV165: 8.9 +/- 2.1; MCF-7: 1.7 +/- 0.5; p < 0.003), as expected from histology. VVF changes were more heterogeneous in the MV165 model both among tumors as well as within tumors as determined 3-dimensionally at submillimeter resolutions. Our results have potential applications for non-invasive assessment of angiogenesis by in vivo imaging and for clinical monitoring during angiogenic therapies. | lld:pubmed |
| pubmed-article:10597197 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10597197 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10597197 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10597197 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10597197 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10597197 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10597197 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10597197 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10597197 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:10597197 | pubmed:author | pubmed-author:LewinMM | lld:pubmed |
| pubmed-article:10597197 | pubmed:author | pubmed-author:WeisslederRR | lld:pubmed |
| pubmed-article:10597197 | pubmed:author | pubmed-author:BredowSS | lld:pubmed |
| pubmed-article:10597197 | pubmed:author | pubmed-author:BogdanovAAJr | lld:pubmed |
| pubmed-article:10597197 | pubmed:author | pubmed-author:MarecosEE | lld:pubmed |
| pubmed-article:10597197 | pubmed:author | pubmed-author:SergeyevNN | lld:pubmed |
| pubmed-article:10597197 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10597197 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:10597197 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:10597197 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10597197 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10597197 | pubmed:pagination | 798-802 | lld:pubmed |
| pubmed-article:10597197 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10597197 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10597197 | pubmed:articleTitle | In vivo assessment of vascular endothelial growth factor-induced angiogenesis. | lld:pubmed |
| pubmed-article:10597197 | pubmed:affiliation | Center for Molecular Imaging Research, Massachusetts General Hospital/Harvard Medical School, Charlestown 02129, USA. | lld:pubmed |
| pubmed-article:10597197 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10597197 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:10597197 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10597197 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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