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rdf:type |
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lifeskim:mentions |
umls-concept:C0024651,
umls-concept:C0079731,
umls-concept:C0242647,
umls-concept:C0332307,
umls-concept:C0599921,
umls-concept:C1442914,
umls-concept:C1511790,
umls-concept:C1515709,
umls-concept:C1517067,
umls-concept:C1548966,
umls-concept:C1979874
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pubmed:issue |
6
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pubmed:dateCreated |
1999-12-28
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pubmed:abstractText |
Extranodal mucosa-associated lymphoid tissue (MALT)-type lymphomas and nodal and splenic marginal zone B cell lymphomas (MZBL) share morphological and immunophenotypic features with marginal zone B cells of reactive lymphoid tissues. Although displaying a similar immunophenotype, recent investigations suggest fundamental genetic differences among these subgroups. To determine the prevalence of the t(11;18) in a larger series of MALT-type lymphomas and to investigate a possible occurrence in other lymphomas, we screened 106 non-Hodgkin's lymphomas (NHL) by interphase cytogenetics using yeast artificial chromosome (YAC) probes flanking the breakpoint at 11q21. A signal constellation indicating a disruption in 11q21 and thus pointing to the presence of the t(11;18) was observed in 9 of 33 (27%) low-grade lymphomas of MALT type. The complete absence of t(11;18)-positive cells in 32 primary and secondary extranodal high-grade lymphomas suggests that low-grade lymphomas of MALT type characterized by the t(11;18) are unlikely to transform into high-grade tumors. The absence of tumor cells carrying the t(11;18) in nodal MZBL challenges the assumption that most, if not all, of these tumors represent the nodal manifestation of a so far undetected low-grade lymphoma of MALT type. The t(11;18) was not detected in a single case of 29 splenic MZBL investigated. This observation strengthens the view that splenic MZBL are biologically different from extranodal MZBL of MALT type.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-10339464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-1373316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-1373320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-1468755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-1609805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-1639408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-1885166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-2200538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-2349966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-2506953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-7534001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-7557915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-7573673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-7688556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-7691710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-7943534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-7949139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-8018922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-8068936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-8136270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-8400252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-8531697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-8547655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-8609731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-8956866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-9181363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-9266948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-9307277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-9375758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-9402171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-9422517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-9736018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-9885983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-9888704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10595910-9927483
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0002-9440
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pubmed:author |
pubmed-author:BredtMM,
pubmed-author:DöhnerHH,
pubmed-author:GawinBB,
pubmed-author:GreinerAA,
pubmed-author:KallaJJ,
pubmed-author:KatzenbergerTT,
pubmed-author:KayR DRD,
pubmed-author:Müller-HermelinkH KHK,
pubmed-author:OttGG,
pubmed-author:RosenwaldAA,
pubmed-author:StilgenbauerSS
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pubmed:issnType |
Print
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pubmed:volume |
155
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1817-21
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10595910-Chromosome Banding,
pubmed-meshheading:10595910-Chromosomes, Human, Pair 11,
pubmed-meshheading:10595910-Chromosomes, Human, Pair 18,
pubmed-meshheading:10595910-Humans,
pubmed-meshheading:10595910-Immunophenotyping,
pubmed-meshheading:10595910-In Situ Hybridization, Fluorescence,
pubmed-meshheading:10595910-Interphase,
pubmed-meshheading:10595910-Lymphoma, B-Cell,
pubmed-meshheading:10595910-Lymphoma, B-Cell, Marginal Zone,
pubmed-meshheading:10595910-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:10595910-Lymphoma, Non-Hodgkin,
pubmed-meshheading:10595910-Translocation, Genetic
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pubmed:year |
1999
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pubmed:articleTitle |
Exclusive detection of the t(11;18)(q21;q21) in extranodal marginal zone B cell lymphomas (MZBL) of MALT type in contrast to other MZBL and extranodal large B cell lymphomas.
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pubmed:affiliation |
Pathologisches Institut, Universität Würzburg, Würzburg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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