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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2000-1-19
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pubmed:abstractText |
Nucleoside boranophosphates are distinctive in that one of the non-bridging oxygens in the phosphate diester 1 is replaced by a borane moiety (BH3). Although they retain the same net charge, BH3(-)-ODN have unique chemical and biochemical characteristics relative to other analogs. The change in polarity, lipophilicity, nuclease resistance, and the activation of RNase H cleavage of RNA in RNA: boranophosphate hybrids make boranophosphates very attractive for applications in enzymology and molecular biology and as potential antisense agents.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0076-6879
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
313
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
226-57
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10595359-Antisense Elements (Genetics),
pubmed-meshheading:10595359-Base Sequence,
pubmed-meshheading:10595359-Boranes,
pubmed-meshheading:10595359-DNA Primers,
pubmed-meshheading:10595359-Indicators and Reagents,
pubmed-meshheading:10595359-Magnetic Resonance Spectroscopy,
pubmed-meshheading:10595359-Molecular Structure,
pubmed-meshheading:10595359-Organophosphorus Compounds,
pubmed-meshheading:10595359-Phosphoric Acid Esters,
pubmed-meshheading:10595359-Polymerase Chain Reaction,
pubmed-meshheading:10595359-Ribonuclease H,
pubmed-meshheading:10595359-Thionucleotides
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pubmed:year |
2000
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pubmed:articleTitle |
Boranophosphate backbone: a mimic of phosphodiesters, phosphorothioates, and methyl phosphonates.
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pubmed:affiliation |
Department of Chemistry, Duke University, Durham, North Carolina 27708-0346, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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