Linked Life Data

10593700

Source:http://linkedlifedata.com/resource/pubmed/id/10593700

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-4-11
pubmed:abstractText
Late-life depression (LLD) is characterized by abnormalities in cerebral blood flow (CBF) and cerebral metabolic rate (CMR) for glucose. Unlike younger adults with major depression, global cortical CBF and CMR reductions have been reported in LLD. Patients with LLD are also characterized by topographic abnormalities, most commonly involving selective prefrontal, superior temporal, and anterior parietal cortex. The fate of these abnormalities with response to antidepressant treatment is highly uncertain, and heterogeneous findings have been reported in younger samples with major depression. The limited data in LLD suggest that response to electroconvulsive therapy or antidepressant medications does not involve reversal of baseline abnormalities but rather accentuation of prefrontal deficits. At minimum, these paradoxical findings suggest that abnormalities in CBF and CMR may be persistent in LLD and a trait characteristic. Characteristic profiles of CBF and CMR abnormalities have also been demonstrated in samples with Alzheimer's disease (AD) and other types of dementia. Functional imaging has shown sensitivity to disease severity and progression. Nonetheless, there is limited information regarding the sensitivity and specificity of the functional imaging modalities in the differential diagnosis of dementias. At present, the evidence does not support the use of functional imaging in isolation as a diagnostic tool. Rather, these imaging modalities may be considered as an adjunct to careful clinical assessment, either to improve diagnosis in early cases or to assist in subtyping difficult cases.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0891-9887
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
118-27
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Cerebral blood flow and metabolism in late-life depression and dementia.
pubmed:affiliation
Department of Biological Psychiatry, New York State Psychiatric Institute, New York 10032, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't