Source:http://linkedlifedata.com/resource/pubmed/id/10591418
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
2000-1-6
|
| pubmed:abstractText |
The main objective of this study was to examine the relation between adverse events and degree of metabolic control and multiple-dose treatment. A total of 139 children, aged between 1 and 18 y, prospectively registered severe hypoglycaemia with or without unconsciousness, as well as hospitalized ketoacidosis, during 1994-95. Treatment from onset was multiple-dose insulin (> 95% > or = 4 doses) combined with intense training and psychosocial support. Median HbA1c was 6.9% (ref. 3.6-5.4%). The incidence of severe hypoglycaemia with unconsciousness was 0.17 events per patient-year, having decreased from the 1970s to the 1990s, parallel to a change from 1-2 to > or = 4 doses per day. There was no correlation or association to the year mean HbA1c for severe hypoglycaemia. Severe hypoglycaemic episodes in 1995 correlated to severe hypoglycaemic episodes in 1994 (r=0.38; p<0.0001). Severe hypoglycaemia with unconsciousness increased during the spring season, and according to case records the assumed causes were mainly mistakes with insulin, food and exercise. Ketoacidosis was rare: 0.015 episodes per patient-year. We conclude that multiple-dose insulin therapy from the very onset of diabetes, combined with adequate self-control, active problem-based training and psycho-social support, may limit severe hypoglycaemia and ketoacidosis. Strategies aimed at minimizing severe hypoglycaemia without compromising metabolic control need to be evaluated.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0803-5253
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
88
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1184-93
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10591418-Adolescent,
pubmed-meshheading:10591418-Blood Glucose,
pubmed-meshheading:10591418-Blood Glucose Self-Monitoring,
pubmed-meshheading:10591418-Child,
pubmed-meshheading:10591418-Child, Preschool,
pubmed-meshheading:10591418-Diabetes Mellitus, Type 1,
pubmed-meshheading:10591418-Diabetic Ketoacidosis,
pubmed-meshheading:10591418-Drug Administration Schedule,
pubmed-meshheading:10591418-Female,
pubmed-meshheading:10591418-Hemoglobin A, Glycosylated,
pubmed-meshheading:10591418-Humans,
pubmed-meshheading:10591418-Hypoglycemia,
pubmed-meshheading:10591418-Infant,
pubmed-meshheading:10591418-Insulin,
pubmed-meshheading:10591418-Male,
pubmed-meshheading:10591418-Patient Compliance,
pubmed-meshheading:10591418-Prognosis,
pubmed-meshheading:10591418-Prospective Studies,
pubmed-meshheading:10591418-Quality of Life,
pubmed-meshheading:10591418-Risk Assessment,
pubmed-meshheading:10591418-Severity of Illness Index,
pubmed-meshheading:10591418-Treatment Outcome,
pubmed-meshheading:10591418-Unconsciousness
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Adverse events in intensively treated children and adolescents with type 1 diabetes.
|
| pubmed:affiliation |
Department of Health and Environment, Faculty of Health Sciences, Linköping, Sweden.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
|