Source:http://linkedlifedata.com/resource/pubmed/id/10591187
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2000-1-4
|
| pubmed:abstractText |
We examined dendritic cell (DC) status in SCID and RAG2 -/- mice to assess the influence of T cells on DC development and function in vivo. These mice have reduced numbers of DC in the epidermis and lymph nodes draining hapten-sensitized skin. Epidermal DC in these mice were defective in presenting antigen in vivo to adoptively transferred, hapten-sensitized T cells from normal mice. Likewise, draining lymph node DC were deficient in their capacity to stimulate naive T cells in vitro and in vivo. DC numbers as well as the impaired ability to present antigen in vivo, were corrected by reconstituting these animals with normal T lymphocytes, suggesting that T cells are crucial for normal DC maturation and function in vivo.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1074-7613
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
625-36
|
| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:10591187-Adoptive Transfer,
pubmed-meshheading:10591187-Animals,
pubmed-meshheading:10591187-Antigen Presentation,
pubmed-meshheading:10591187-Cell Count,
pubmed-meshheading:10591187-Cell Differentiation,
pubmed-meshheading:10591187-DNA-Binding Proteins,
pubmed-meshheading:10591187-Dendritic Cells,
pubmed-meshheading:10591187-Dermatitis, Allergic Contact,
pubmed-meshheading:10591187-Epidermis,
pubmed-meshheading:10591187-Haptens,
pubmed-meshheading:10591187-Langerhans Cells,
pubmed-meshheading:10591187-Lymph Nodes,
pubmed-meshheading:10591187-Mice,
pubmed-meshheading:10591187-Mice, Inbred BALB C,
pubmed-meshheading:10591187-Mice, Inbred C3H,
pubmed-meshheading:10591187-Mice, Inbred C57BL,
pubmed-meshheading:10591187-Mice, Knockout,
pubmed-meshheading:10591187-Mice, SCID,
pubmed-meshheading:10591187-T-Lymphocyte Subsets
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Dendritic cells require T cells for functional maturation in vivo.
|
| pubmed:affiliation |
Department of Immunology, The University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|