Source:http://linkedlifedata.com/resource/pubmed/id/10589618
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
1999-12-30
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| pubmed:abstractText |
We studied the hemodynamic effects of propofol during elective cardiac catheterization in 30 children with congenital heart disease. Sixteen patients were without cardiac shunt (Group I), six had left-to-right cardiac shunt (Group II), and eight had right-to-left cardiac shunt (Group III). The mean (+/-SD) ages were 3.8+/-3.1 yr (Group I), 3.2+/-3.7 yr (Group II), and 1.0+/-0.6 yr (Group III). After sedation and cardiac catheter insertion, hemodynamic data and oxygen consumption were measured before and after the administration of propofol (2-mg/kg bolus, 50- to 200-microg x kg(-1) x min(-1) infusion), and values were compared by using a paired t-test (significance: P < 0.05). After the propofol administration, systemic mean arterial pressure and systemic vascular resistance decreased significantly and systemic blood flow increased significantly in all patient groups; heart rate, pulmonary mean arterial pressure, and pulmonary vascular resistance were unchanged. Pulmonary to systemic resistance ratio increased (Group I, P = 0.005; Group II, P = 0.03; Group III, P = 0.10). In patients with cardiac shunt, propofol resulted in decreased left-to-right flow and increased right-to-left flow; the pulmonary to systemic flow ratio decreased significantly (Group II, P = 0.005; Group III, P = 0.01). Clinically relevant decreases in Pao2 (P = 0.008) and Sao2 (P = 0.01) occurred in Group III patients. We conclude that propofol can result in clinically important changes in cardiac shunt direction and flow. IMPLICATIONS: The principal hemodynamic effect of propofol in children with congenital heart defects is a decrease in systemic vascular resistance. In children with cardiac shunt, this results in a decrease in the ratio of pulmonary to systemic blood flow, and it can lead to arterial desaturation in patients with cyanotic heart disease.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
0003-2999
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
89
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1411-6
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10589618-Anesthesia, General,
pubmed-meshheading:10589618-Anesthetics, Intravenous,
pubmed-meshheading:10589618-Blood Pressure,
pubmed-meshheading:10589618-Carbon Dioxide,
pubmed-meshheading:10589618-Child,
pubmed-meshheading:10589618-Child, Preschool,
pubmed-meshheading:10589618-Female,
pubmed-meshheading:10589618-Heart Catheterization,
pubmed-meshheading:10589618-Heart Defects, Congenital,
pubmed-meshheading:10589618-Hemodynamics,
pubmed-meshheading:10589618-Humans,
pubmed-meshheading:10589618-Infant,
pubmed-meshheading:10589618-Male,
pubmed-meshheading:10589618-Oxygen Consumption,
pubmed-meshheading:10589618-Partial Pressure,
pubmed-meshheading:10589618-Propofol,
pubmed-meshheading:10589618-Pulmonary Circulation,
pubmed-meshheading:10589618-Vascular Resistance
|
| pubmed:year |
1999
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| pubmed:articleTitle |
The hemodynamic effects of propofol in children with congenital heart disease.
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| pubmed:affiliation |
Department of Anesthesiology, University of Washington School of Medicine and Children's Hospital and Regional Medical Center, Seattle 98105, USA.
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| pubmed:publicationType |
Journal Article,
Clinical Trial
|