Linked Life Data

10589610

Source:http://linkedlifedata.com/resource/pubmed/id/10589610

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1999-12-30
pubmed:abstractText
The purpose of our study was to investigate the effects of sodium nitroprusside-induced hypotension on splanchnic perfusion and hepatocellular integrity. Thirty patients undergoing radical prostatectomy were allocated randomly to a sodium nitroprusside (SNP) or control group (control). Regional pco2 was measured using gastric tonometry, and the regional to arterial difference in partial pressure of CO2 and intramucosal pH were calculated. The cytosolic liver enzyme alpha-glutathione S-transferase and standard liver enzyme markers (alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyltransferase) were also measured. Mean arterial pressure in the SNP group was 50 mm Hg for 97 min during surgery. A significant increase from baseline in regional pco2 (from 40.0+/-4.2 mm Hg to 45.3+/-1.3 mm Hg) and regional to arterial difference in partial pressure of CO2 (from 4.1+/-1.1 mm Hg to 9.7+/-1.4 mm Hg) was seen at 90 min after skin incision only in the SNP group. Intramucosal pH decreased significantly from 7.40+/-0.02 to 7.35+/-0.03 during the same period in this group. Tonometric variables returned to baseline values within 2 h postoperatively. Alpha-glutathione S-transferase concentrations increased significantly in the SNP group from baseline to peak concentrations at the end of surgery (SNP: 9.93+/-4.94 microg/L; control: 5.85+/-1.86 microg/L). A return to baseline values was seen 24 h postoperatively. No significant changes in standard liver enzyme markers were seen throughout the study period. It is concluded, that splanchnic perfusion was transiently impaired during controlled hypotension. This is supported by significant changes in tonometric data. Increased serum levels of alpha-glutathione S-transferase may indicate a disturbance in hepatocellular integrity. IMPLICATIONS: We studied gastric mucosal tonometry and the cytosolic liver enzyme alpha-glutathione S-transferase to evaluate the effects of controlled hypotension induced by sodium nitroprusside on splanchnic perfusion and hepatocellular integrity. Splanchnic perfusion decreased and alpha-glutathione S-transferase increased during and after a hypotensive period, but returned to baseline values within the first postoperative day, indicating a transient impairment of splanchnic perfusion and hepatocellular integrity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0003-2999
pubmed:author
pubmed:issnType
Print
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1371-7
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:10589610-Antihypertensive Agents, pubmed-meshheading:10589610-Biological Markers, pubmed-meshheading:10589610-Blood Pressure, pubmed-meshheading:10589610-Carbon Dioxide, pubmed-meshheading:10589610-Drug-Induced Liver Injury, pubmed-meshheading:10589610-Glutathione Transferase, pubmed-meshheading:10589610-Humans, pubmed-meshheading:10589610-Hypotension, pubmed-meshheading:10589610-Isoenzymes, pubmed-meshheading:10589610-Liver, pubmed-meshheading:10589610-Liver Diseases, pubmed-meshheading:10589610-Male, pubmed-meshheading:10589610-Middle Aged, pubmed-meshheading:10589610-Nitroprusside, pubmed-meshheading:10589610-Oxygen, pubmed-meshheading:10589610-Partial Pressure, pubmed-meshheading:10589610-Prostatectomy, pubmed-meshheading:10589610-Splanchnic Circulation, pubmed-meshheading:10589610-Vasodilator Agents
pubmed:year
1999
pubmed:articleTitle
The effects of sodium nitroprusside-induced hypotension on splanchnic perfusion and hepatocellular integrity.
pubmed:affiliation
Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Akademisches Lehrkrankenhaus der Universität Mainz, Germany.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial