Linked Life Data

10588867

Source:http://linkedlifedata.com/resource/pubmed/id/10588867

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2000-1-11
pubmed:abstractText
The intestine of Caenorhabditis elegans is an epithelial tube consisting of only 20 cells and is derived clonally from a single embryonic blastomere called E. We describe the cellular events that shape the intestine. These events include cytoplasmic polarization of cells in the intestinal primordium, the intercalation of specific sets of cells, the generation of an extracellular cavity within the primordium, and adherens junction formation. The polarization of the intestinal primordium is associated with the generation of an asymmetric microtubule cytoskeleton, and microtubule function plays a role in subsequent cell polarity. We show that an isolated E blastomere is capable of generating polarized intestinal cells, indicating that some of the major events in intestinal organogenesis do not depend upon interactions with surrounding tissues. We compare and contrast intestinal organogenesis with some of the basic steps in development of a second epithelial organ, the pharynx, and suggest how these differences lead to organs with distinct shapes.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0012-1606
pubmed:author
pubmed:copyrightInfo
Copyright 1999 Academic Press.
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
216
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
114-34
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Organogenesis of the Caenorhabditis elegans intestine.
pubmed:affiliation
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't