| pubmed-article:10586040 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10586040 | lifeskim:mentions | umls-concept:C0022688 | lld:lifeskim |
| pubmed-article:10586040 | lifeskim:mentions | umls-concept:C0019629 | lld:lifeskim |
| pubmed-article:10586040 | lifeskim:mentions | umls-concept:C0596402 | lld:lifeskim |
| pubmed-article:10586040 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:10586040 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10586040 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:10586040 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:10586040 | pubmed:dateCreated | 2000-1-6 | lld:pubmed |
| pubmed-article:10586040 | pubmed:abstractText | Activation of NK cells by target cells leads to cytotoxicity as well as production of various cytokines including IFN-gamma. MHC class I molecules on target cells regulate NK cytotoxicity. However, little is known about the regulation of IFN-gamma production by NK cells. We examined the production of IFN-gamma in individual murine NK cells stimulated with tumor cell lines by flow cytometric analysis of intracellular IFN-gamma. Among several tumor lines tested, the rat basophilic leukemia line RBL-1 induced particularly high level of IFN-gamma production in IL-2-activated NK cells, whereas other lines, including the prototypic NK target YAC-1, induced very low or no IFN-gamma production. Transfection of murine classical MHC class I molecules into RBL-1 cells substantially inhibited IFN-gamma production. This inhibition of IFN-gamma production by MHC class I was independent of Ly-49 or CD94/NKG2A expression on NK cells. These results indicate that some target cells directly stimulate IL-2-activated NK cells and induce IFN-gamma production, but the requirements for the induction of IFN-gamma production seem different from those for NK cytotoxicity. Furthermore, similar to NK cytotoxicity, induction of IFN-gamma production is inhibited by MHC class I on stimulating cells. However, the MHC class I-specific receptors inhibiting IFN-gamma production are different from those for NK cytotoxicity. | lld:pubmed |
| pubmed-article:10586040 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10586040 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10586040 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10586040 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10586040 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10586040 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10586040 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10586040 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10586040 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10586040 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10586040 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10586040 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10586040 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10586040 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10586040 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:10586040 | pubmed:author | pubmed-author:KubotaAA | lld:pubmed |
| pubmed-article:10586040 | pubmed:author | pubmed-author:TakeiFF | lld:pubmed |
| pubmed-article:10586040 | pubmed:author | pubmed-author:SalcedoMM | lld:pubmed |
| pubmed-article:10586040 | pubmed:author | pubmed-author:LevyD HDH | lld:pubmed |
| pubmed-article:10586040 | pubmed:author | pubmed-author:LohwasserSS | lld:pubmed |
| pubmed-article:10586040 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10586040 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10586040 | pubmed:volume | 163 | lld:pubmed |
| pubmed-article:10586040 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10586040 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10586040 | pubmed:pagination | 6488-93 | lld:pubmed |
| pubmed-article:10586040 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:10586040 | pubmed:meshHeading | pubmed-meshheading:10586040... | lld:pubmed |
| pubmed-article:10586040 | pubmed:meshHeading | pubmed-meshheading:10586040... | lld:pubmed |
| pubmed-article:10586040 | pubmed:meshHeading | pubmed-meshheading:10586040... | lld:pubmed |
| pubmed-article:10586040 | pubmed:meshHeading | pubmed-meshheading:10586040... | lld:pubmed |
| pubmed-article:10586040 | pubmed:meshHeading | pubmed-meshheading:10586040... | lld:pubmed |
| pubmed-article:10586040 | pubmed:meshHeading | pubmed-meshheading:10586040... | lld:pubmed |
| pubmed-article:10586040 | pubmed:meshHeading | pubmed-meshheading:10586040... | lld:pubmed |
| pubmed-article:10586040 | pubmed:meshHeading | pubmed-meshheading:10586040... | lld:pubmed |
| pubmed-article:10586040 | pubmed:meshHeading | pubmed-meshheading:10586040... | lld:pubmed |
| pubmed-article:10586040 | pubmed:meshHeading | pubmed-meshheading:10586040... | lld:pubmed |
| pubmed-article:10586040 | pubmed:meshHeading | pubmed-meshheading:10586040... | lld:pubmed |
| pubmed-article:10586040 | pubmed:meshHeading | pubmed-meshheading:10586040... | lld:pubmed |
| pubmed-article:10586040 | pubmed:meshHeading | pubmed-meshheading:10586040... | lld:pubmed |
| pubmed-article:10586040 | pubmed:meshHeading | pubmed-meshheading:10586040... | lld:pubmed |
| pubmed-article:10586040 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10586040 | pubmed:articleTitle | IFN-gamma production and cytotoxicity of IL-2-activated murine NK cells are differentially regulated by MHC class I molecules. | lld:pubmed |
| pubmed-article:10586040 | pubmed:affiliation | Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, Canada. | lld:pubmed |
| pubmed-article:10586040 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10586040 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
