Source:http://linkedlifedata.com/resource/pubmed/id/10586040
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2000-1-6
|
| pubmed:abstractText |
Activation of NK cells by target cells leads to cytotoxicity as well as production of various cytokines including IFN-gamma. MHC class I molecules on target cells regulate NK cytotoxicity. However, little is known about the regulation of IFN-gamma production by NK cells. We examined the production of IFN-gamma in individual murine NK cells stimulated with tumor cell lines by flow cytometric analysis of intracellular IFN-gamma. Among several tumor lines tested, the rat basophilic leukemia line RBL-1 induced particularly high level of IFN-gamma production in IL-2-activated NK cells, whereas other lines, including the prototypic NK target YAC-1, induced very low or no IFN-gamma production. Transfection of murine classical MHC class I molecules into RBL-1 cells substantially inhibited IFN-gamma production. This inhibition of IFN-gamma production by MHC class I was independent of Ly-49 or CD94/NKG2A expression on NK cells. These results indicate that some target cells directly stimulate IL-2-activated NK cells and induce IFN-gamma production, but the requirements for the induction of IFN-gamma production seem different from those for NK cytotoxicity. Furthermore, similar to NK cytotoxicity, induction of IFN-gamma production is inhibited by MHC class I on stimulating cells. However, the MHC class I-specific receptors inhibiting IFN-gamma production are different from those for NK cytotoxicity.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Ly,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, KIR,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, NK Cell Lectin-Like
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
163
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
6488-93
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:10586040-Animals,
pubmed-meshheading:10586040-Antigens, Ly,
pubmed-meshheading:10586040-Binding Sites,
pubmed-meshheading:10586040-Cytotoxicity, Immunologic,
pubmed-meshheading:10586040-Histocompatibility Antigens Class I,
pubmed-meshheading:10586040-Interferon-gamma,
pubmed-meshheading:10586040-Interleukin-2,
pubmed-meshheading:10586040-Killer Cells, Natural,
pubmed-meshheading:10586040-Lectins, C-Type,
pubmed-meshheading:10586040-Lymphocyte Activation,
pubmed-meshheading:10586040-Membrane Glycoproteins,
pubmed-meshheading:10586040-Mice,
pubmed-meshheading:10586040-Mice, Inbred C57BL,
pubmed-meshheading:10586040-Rats,
pubmed-meshheading:10586040-Receptors, Immunologic,
pubmed-meshheading:10586040-Receptors, KIR,
pubmed-meshheading:10586040-Receptors, NK Cell Lectin-Like,
pubmed-meshheading:10586040-Tumor Cells, Cultured
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
IFN-gamma production and cytotoxicity of IL-2-activated murine NK cells are differentially regulated by MHC class I molecules.
|
| pubmed:affiliation |
Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, Canada.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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