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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5446
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pubmed:dateCreated |
1999-12-16
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pubmed:abstractText |
Follicle-associated epithelium (FAE) in the intestinal Peyer's patches contains M cells that deliver pathogens to organized lymphoid tissue. Development of Peyer's patches, FAE, and M cells was found to be impaired in mice that had no B cells. Transgenic expression of membrane-bound immunoglobulin M restored B cells and FAE development. The lack of M cells abrogated infection with a milk-borne retrovirus. Thus, in addition to secretion of antibodies and presentation of antigens, B cells are important for organogenesis of the mucosal immune barriers.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
286
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1965-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10583962-Animals,
pubmed-meshheading:10583962-B-Lymphocytes,
pubmed-meshheading:10583962-Cell Count,
pubmed-meshheading:10583962-Genes, Immunoglobulin,
pubmed-meshheading:10583962-Immunity, Mucosal,
pubmed-meshheading:10583962-Immunoglobulin M,
pubmed-meshheading:10583962-Lymphocyte Activation,
pubmed-meshheading:10583962-Mammary Tumor Virus, Mouse,
pubmed-meshheading:10583962-Mice,
pubmed-meshheading:10583962-Mice, Inbred Strains,
pubmed-meshheading:10583962-Mice, Knockout,
pubmed-meshheading:10583962-Mice, Transgenic,
pubmed-meshheading:10583962-Microscopy, Electron, Scanning,
pubmed-meshheading:10583962-Peyer's Patches,
pubmed-meshheading:10583962-Retroviridae Infections,
pubmed-meshheading:10583962-T-Lymphocytes,
pubmed-meshheading:10583962-Tumor Virus Infections
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pubmed:year |
1999
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pubmed:articleTitle |
Organogenic role of B lymphocytes in mucosal immunity.
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pubmed:affiliation |
Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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