Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5446
pubmed:dateCreated
1999-12-16
pubmed:abstractText
Eighteen codons in the HA1 domain of the hemagglutinin genes of human influenza A subtype H3 appear to be under positive selection to change the amino acid they encode. Retrospective tests show that viral lineages undergoing the greatest number of mutations in the positively selected codons were the progenitors of future H3 lineages in 9 of 11 recent influenza seasons. Codons under positive selection were associated with antibody combining site A or B or the sialic acid receptor binding site. However, not all codons in these sites had predictive value. Monitoring new H3 isolates for additional changes in positively selected codons might help identify the most fit extant viral strains that arise during antigenic drift.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0036-8075
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
286
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1921-5
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:10583948-Amino Acid Substitution, pubmed-meshheading:10583948-Antigenic Variation, pubmed-meshheading:10583948-Binding Sites, pubmed-meshheading:10583948-Codon, pubmed-meshheading:10583948-Epitopes, pubmed-meshheading:10583948-Evolution, Molecular, pubmed-meshheading:10583948-Forecasting, pubmed-meshheading:10583948-Genes, Viral, pubmed-meshheading:10583948-Hemagglutinin Glycoproteins, Influenza Virus, pubmed-meshheading:10583948-Humans, pubmed-meshheading:10583948-Influenza, Human, pubmed-meshheading:10583948-Influenza A virus, pubmed-meshheading:10583948-Mutation, pubmed-meshheading:10583948-Phylogeny, pubmed-meshheading:10583948-Probability, pubmed-meshheading:10583948-Protein Structure, Tertiary, pubmed-meshheading:10583948-Receptors, Cell Surface, pubmed-meshheading:10583948-Retrospective Studies, pubmed-meshheading:10583948-Selection, Genetic
pubmed:year
1999
pubmed:articleTitle
Predicting the evolution of human influenza A.
pubmed:affiliation
Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA. rmbush@uci.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't