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rdf:type |
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lifeskim:mentions |
umls-concept:C0010068,
umls-concept:C0030705,
umls-concept:C0031667,
umls-concept:C0033105,
umls-concept:C0037047,
umls-concept:C0205252,
umls-concept:C0245726,
umls-concept:C1418617,
umls-concept:C1706169,
umls-concept:C1706170,
umls-concept:C1882417
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pubmed:issue |
12
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pubmed:dateCreated |
2000-1-6
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pubmed:abstractText |
The Pl(A2) polymorphism of GPIIIa has been associated with unstable coronary syndromes in some studies, but the association has remained debated. None of the previous studies have focused on families at high risk. Risk factors tend to cluster within kindreds with high prevalence of premature coronary heart disease (CHD). Therefore, a heightened prevalence of the Pl(A2) polymorphism among siblings of patients with CHD would support the hypothesis that Pl(A2) is linked, directly or indirectly, to CHD.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0003-9985
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pubmed:author |
pubmed-author:BeckerD MDM,
pubmed-author:BeckerL CLC,
pubmed-author:BlumenthalR SRS,
pubmed-author:BrayP FPF,
pubmed-author:ColemanL DLD,
pubmed-author:CookeG EGE,
pubmed-author:Goldschmidt-ClermontP JPJ,
pubmed-author:HueyW CWC,
pubmed-author:LIMR KRK,
pubmed-author:PhamY MYM,
pubmed-author:ShearW SWS,
pubmed-author:WeissE JEJ,
pubmed-author:YookR MRM
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pubmed:issnType |
Print
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pubmed:volume |
123
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1223-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10583927-Adult,
pubmed-meshheading:10583927-Antigens, CD,
pubmed-meshheading:10583927-Cohort Studies,
pubmed-meshheading:10583927-Coronary Disease,
pubmed-meshheading:10583927-Female,
pubmed-meshheading:10583927-Gene Frequency,
pubmed-meshheading:10583927-Genotype,
pubmed-meshheading:10583927-Humans,
pubmed-meshheading:10583927-Integrin beta3,
pubmed-meshheading:10583927-Male,
pubmed-meshheading:10583927-Middle Aged,
pubmed-meshheading:10583927-Platelet Function Tests,
pubmed-meshheading:10583927-Platelet Membrane Glycoproteins,
pubmed-meshheading:10583927-Polymorphism, Genetic,
pubmed-meshheading:10583927-Risk Factors
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pubmed:year |
1999
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pubmed:articleTitle |
Higher prevalence of GPIIIa PlA2 polymorphism in siblings of patients with premature coronary heart disease.
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pubmed:affiliation |
Heart and Lung Institute and the Division of Cardiology, College of Medicine and Public Health, The Ohio State University, Columbus 43210, USA. goldschmidt-1@medctr.osu.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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