Source:http://linkedlifedata.com/resource/pubmed/id/10582788
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
1999-12-30
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| pubmed:abstractText |
The current pandemic of sexually transmitted human immunodeficiency virus (HIV) infection--the causative agent of acquired immunodeficiency syndrome (AIDS), has created an urgent need for a new type of contraceptive: one that is both a spermicide and a microbicide. Because most women at risk for HIV infection are of reproductive age (15-44 years), effective use of dual-function contraceptives is important to prevent HIV transmission and unintended pregnancies. In the absence of an effective prophylactic anti-HIV therapy or vaccine, new emphasis has been placed on the development of intravaginal microbicidal agents capable of reducing the transmission of HIV. Topical microbicidal spermicides would ideally provide a female-controlled method of self-protection against HIV as well as preventing pregnancy. However, several microbicides that are undergoing preclinical and human clinical trials contain detergent-type ingredients. The detergent-type spermicide, nonoxynol-9, the only recommended microbicide for protection against sexual transmission of HIV has been shown to cause lesions in vaginal and cervical epithelia leaving women more vulnerable to HIV infection. Therefore, a major challenge in microbicide research has been to design mechanism-based microbicides that are highly effective against pregnancy and HIV transmission while lacking detergent-type effects on epithelial cells and normal vaginal flora. We present an overview of current microbicide research and report on the identification and preclinical development of novel non-detergent spermicidal nucleoside and non-nucleoside inhibitors aimed at decreasing pregnancy and preventing sexual transmission of HIV.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
1355-4786
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
5
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
506-14
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:10582788-Animals,
pubmed-meshheading:10582788-Anti-HIV Agents,
pubmed-meshheading:10582788-Condoms,
pubmed-meshheading:10582788-Contraception,
pubmed-meshheading:10582788-Drug Evaluation,
pubmed-meshheading:10582788-Drug Evaluation, Preclinical,
pubmed-meshheading:10582788-Female,
pubmed-meshheading:10582788-HIV,
pubmed-meshheading:10582788-HIV Infections,
pubmed-meshheading:10582788-Haplorhini,
pubmed-meshheading:10582788-Humans,
pubmed-meshheading:10582788-Irritants,
pubmed-meshheading:10582788-Male,
pubmed-meshheading:10582788-Mucous Membrane,
pubmed-meshheading:10582788-Risk-Taking,
pubmed-meshheading:10582788-Sexual Behavior,
pubmed-meshheading:10582788-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:10582788-Spermatocidal Agents,
pubmed-meshheading:10582788-Structure-Activity Relationship,
pubmed-meshheading:10582788-Surface-Active Agents,
pubmed-meshheading:10582788-Vagina
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| pubmed:articleTitle |
Prophylactic contraceptives for HIV/AIDS.
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| pubmed:affiliation |
Department of Virology, Hughes Institute, St Paul, Minnesota 55113, USA. faith_uckun@mercury.ih.org
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review
|