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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
1999-12-14
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pubmed:abstractText |
Chromosome 8p21-22 is a frequent site of allelic deletions in many types of human tumors, including non-small cell lung cancer (NSCLC). Tumor necrosis factor-related apoptosis-inducing ligand-receptor 2 (TRAIL-R2) is a cell-surface receptor involved in cell death signaling. The TRAIL-R2 gene recently has been mapped to chromosome 8p21-22. To explore the possibility that the TRAIL-R2 gene might be the relevant gene to the frequent deletion of 8p21-22 in NSCLC, we have analyzed the entire coding region and all splice sites of TRAIL-R2 for the detection of the somatic mutations in a series of 104 NSCLCs. Overall, 11 tumors (10.6%) were found to have TRAIL-R2 gene mutations in the death domain known to be involved in the transduction of an apoptotic signal. Our data indicate that somatic mutation of TRAIL-R2 may play a role in the pathogenesis of some NSCLCs and that the TRAIL-R2 gene is one of the genes relevant to the frequent loss of chromosome 8p21-22 in NSCLC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0008-5472
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pubmed:author |
pubmed-author:HanJ YJY,
pubmed-author:JangJ JJJ,
pubmed-author:KimH SHS,
pubmed-author:KimS YSY,
pubmed-author:LeeH KHK,
pubmed-author:LeeJ HJH,
pubmed-author:LeeJ YJY,
pubmed-author:LeeS HSH,
pubmed-author:ParkJ YJY,
pubmed-author:ParkW SWS,
pubmed-author:QuS FSF,
pubmed-author:RAOK NKN,
pubmed-author:ShinM SMS,
pubmed-author:YooN JNJ
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5683-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10582684-Adenocarcinoma,
pubmed-meshheading:10582684-Amino Acid Sequence,
pubmed-meshheading:10582684-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:10582684-Carcinoma, Squamous Cell,
pubmed-meshheading:10582684-Chromosomes, Human, Pair 8,
pubmed-meshheading:10582684-Humans,
pubmed-meshheading:10582684-Loss of Heterozygosity,
pubmed-meshheading:10582684-Lung Neoplasms,
pubmed-meshheading:10582684-Molecular Sequence Data,
pubmed-meshheading:10582684-Mutation,
pubmed-meshheading:10582684-Mutation, Missense,
pubmed-meshheading:10582684-Polymerase Chain Reaction,
pubmed-meshheading:10582684-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:10582684-Receptors, TNF-Related Apoptosis-Inducing Ligand,
pubmed-meshheading:10582684-Receptors, Tumor Necrosis Factor
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pubmed:year |
1999
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pubmed:articleTitle |
Alterations of the DR5/TRAIL receptor 2 gene in non-small cell lung cancers.
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pubmed:affiliation |
Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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