Linked Life Data

10582123

Source:http://linkedlifedata.com/resource/pubmed/id/10582123

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1999-12-14
pubmed:abstractText
Human 5-HT3 receptors expressed in HEK 293 cells were studied using patch-clamp techniques. The permeability ratios of cations to Na+ were Li+, 1.16; K+, 1.04; Rb+, 1.11; Cs+, 1.11; NMDG+, 0.04; Ca2+, 0.49, and Mg2+, 0.37. The permeability sequence of the alkali metal cations was Li+ > Rb+ = Cs+ > K+ > Na+. Increased external concentrations of Ca2+ or Mg2- decreased 5-HT-induced currents at all potentials tested in a voltage-independent manner. The single-channel conductance of human 5-HT3 receptors measured by fluctuation analysis of whole-cell currents was 790 +/- 100 fS. Differences in the basic properties of 5-HT3 receptors between species may explain interspecies differences in pharmacological properties.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0939-4451
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
243-55
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Ion permeation properties of a cloned human 5-HT3 receptor transiently expressed in HEK 293 cells.
pubmed:affiliation
Molecular Medicine Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Ibaraki, Japan. mochizuk@yamanouchi.co.jp
pubmed:publicationType
Journal Article