Source:http://linkedlifedata.com/resource/pubmed/id/10580898
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1999-12-13
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| pubmed:abstractText |
Cervical cancer was treated with a combination of external beam and intracavitary radiation during a 10-year period at Wayne State University. Data were collected for 216 patients treated radically with external beam radiation (EBRT) and low-dose-rate brachytherapy for cervical cancer between 1980 and 1991 at Wayne State University. Patient distribution by stage was IB, 20.8%; IIA, 7.4%; IIB, 26.9%; IIIA, 1.8%; IIIB, 40.7%; and IVA, 2.3 %. Survival curves were constructed using Kaplan-Meier methods and differences between groups were tested for significance using the log-rank test. Multivariate analysis was done using the Cox proportional hazards model. With a median follow-up of 114 months, actuarial disease-free survival for all patients was 60% at 5 years and 55% at 10 years. Actuarial 5-year survival for Stage IB was 79%; for Stage II, 59%; and for Stage III, 53%. There were 14/216 (6%) of patients with severe late complications. On univariate analysis, race was found to be statistically significant, with Caucasian patients having better survival than African American (P = 0.03). The survival for patients treated in shorter overall times was significantly higher (P<0.001), especially with treatment completion in under 58 days. The stepwise Cox multivariate analysis provided the following significant results: race (African American vs. Caucasian; P = 0.04, RR = 1.6), Stage (II vs. I, P = 0.004, RR = 2.6), Stage (III vs. I; P = 0.004, RR = 2.5), and overall treatment time (P = 0.006, RR = 1.62). Rates of local control, survival, and complications among women treated with combined external beam and intracavitary radiation for cervix cancer were similar to those of prior retrospective studies.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:issn |
1065-7541
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
7
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
289-96
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| pubmed:dateRevised |
2005-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10580898-Actuarial Analysis,
pubmed-meshheading:10580898-Adenocarcinoma,
pubmed-meshheading:10580898-Adult,
pubmed-meshheading:10580898-African Continental Ancestry Group,
pubmed-meshheading:10580898-Analysis of Variance,
pubmed-meshheading:10580898-Brachytherapy,
pubmed-meshheading:10580898-Carcinoma, Squamous Cell,
pubmed-meshheading:10580898-Disease-Free Survival,
pubmed-meshheading:10580898-European Continental Ancestry Group,
pubmed-meshheading:10580898-Female,
pubmed-meshheading:10580898-Follow-Up Studies,
pubmed-meshheading:10580898-Humans,
pubmed-meshheading:10580898-Linear Models,
pubmed-meshheading:10580898-Middle Aged,
pubmed-meshheading:10580898-Multivariate Analysis,
pubmed-meshheading:10580898-Neoplasm Staging,
pubmed-meshheading:10580898-Proportional Hazards Models,
pubmed-meshheading:10580898-Radiotherapy Dosage,
pubmed-meshheading:10580898-Remission Induction,
pubmed-meshheading:10580898-Retrospective Studies,
pubmed-meshheading:10580898-Survival Rate,
pubmed-meshheading:10580898-Time Factors,
pubmed-meshheading:10580898-Uterine Cervical Neoplasms
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| pubmed:year |
1999
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| pubmed:articleTitle |
Combined low-dose-rate brachytherapy and external beam radiation for cervical cancer: experience over ten years.
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| pubmed:affiliation |
Department of Radiation Oncology, Barbara Ann Karmanos Cancer Center, Detroit, Michigan, USA. hanihn@karmanos.org
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| pubmed:publicationType |
Journal Article
|