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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-1-6
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pubmed:abstractText |
Rearrangements of the short arm of chromosome 12 are frequently observed in hematological disorders. Previous studies of loss of heterozygosity identified a small genetic interval on chromosome 12p12.3 that is frequently deleted in childhood acute lymphoblastic leukemia (ALL). Two genes, ETV6/TEL and p27/KIP1, are located in this interval. Evidence has accumulated that an as-yet unidentified tumor suppressor gene is closely linked to these. To facilitate the identification of candidate genes, a long-range high-resolution restriction map of the ALL locus was constructed using a contig of YAC clones. Several marker loci, including 11 STS, three newly developed YAC end-based STS, six EST, and seven genes were unambiguously positioned in the new map. The map covers 1.8Mb and extends from the distal salivary proline-rich protein gene cluster to the proximal p27/KIP1 gene. The data confirmed the order tel-D12S358-p27/KIP1-cen and excluded p27/KIP1 as a candidate tumor suppressor gene. The critical region delimited by D12S89 and D12S358 is a 750kb CpG-island rich region that includes the 240kb TEL/ETV6 gene as well as CLAPS3 (clathrin-adaptor small chain 3). The new map provides a molecular framework for the identification of novel genes and transcriptional units in the ALL interval.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AP3S1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Protein Complex 3,
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Protein Complex sigma...,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ETS translocation variant 6 protein,
http://linkedlifedata.com/resource/pubmed/chemical/Microtubule-Associated Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-ets,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0378-1119
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
240
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
297-305
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10580149-Adaptor Protein Complex 3,
pubmed-meshheading:10580149-Adaptor Protein Complex sigma Subunits,
pubmed-meshheading:10580149-Animals,
pubmed-meshheading:10580149-Cell Cycle Proteins,
pubmed-meshheading:10580149-Child,
pubmed-meshheading:10580149-Chromosomes, Artificial, Yeast,
pubmed-meshheading:10580149-Chromosomes, Human, Pair 12,
pubmed-meshheading:10580149-Contig Mapping,
pubmed-meshheading:10580149-Cricetinae,
pubmed-meshheading:10580149-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:10580149-DNA,
pubmed-meshheading:10580149-DNA-Binding Proteins,
pubmed-meshheading:10580149-Expressed Sequence Tags,
pubmed-meshheading:10580149-Humans,
pubmed-meshheading:10580149-Hybrid Cells,
pubmed-meshheading:10580149-Microsatellite Repeats,
pubmed-meshheading:10580149-Microtubule-Associated Proteins,
pubmed-meshheading:10580149-Nerve Tissue Proteins,
pubmed-meshheading:10580149-Peptides,
pubmed-meshheading:10580149-Physical Chromosome Mapping,
pubmed-meshheading:10580149-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:10580149-Proline-Rich Protein Domains,
pubmed-meshheading:10580149-Proto-Oncogene Proteins c-ets,
pubmed-meshheading:10580149-Repressor Proteins,
pubmed-meshheading:10580149-Sequence Tagged Sites,
pubmed-meshheading:10580149-Transcription, Genetic,
pubmed-meshheading:10580149-Transcription Factors,
pubmed-meshheading:10580149-Tumor Suppressor Proteins
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pubmed:year |
1999
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pubmed:articleTitle |
Fine physical and transcript mapping of a 1.8 Mb region spanning the locus for childhood acute lymphoblastic leukemia on chromosome 12p12. 3.
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pubmed:affiliation |
Division of Hematology-Oncology, Charles-Bruneau Cancer Center, Research Center, Sainte-Justine Hospital, 3175 Côte Ste-Catherine, Montreal, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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