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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
1999-12-21
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pubmed:abstractText |
Patients with acute lymphoblastic leukemia are often treated with 6-mercaptopurine, and those with homozygous deficiency in thiopurine S-methyltransferase (TPMT) enzyme activity have an extreme sensitivity to this drug as a result of the accumulation of higher cellular concentrations of thioguanine nucleotides. We studied the metabolism, dose requirements, and tolerance of 6-mercaptopurine among patients with different TPMT phenotypes.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8874
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2001-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10580024-6-Mercaptopurine,
pubmed-meshheading:10580024-Antimetabolites, Antineoplastic,
pubmed-meshheading:10580024-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:10580024-Area Under Curve,
pubmed-meshheading:10580024-Child,
pubmed-meshheading:10580024-Erythrocytes,
pubmed-meshheading:10580024-Female,
pubmed-meshheading:10580024-Guanine Nucleotides,
pubmed-meshheading:10580024-Heterozygote,
pubmed-meshheading:10580024-Humans,
pubmed-meshheading:10580024-Male,
pubmed-meshheading:10580024-Methylation,
pubmed-meshheading:10580024-Methyltransferases,
pubmed-meshheading:10580024-Phenotype,
pubmed-meshheading:10580024-Polymorphism, Genetic,
pubmed-meshheading:10580024-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:10580024-Prodrugs,
pubmed-meshheading:10580024-Thionucleotides
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pubmed:year |
1999
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pubmed:articleTitle |
Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus.
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pubmed:affiliation |
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. mary.relling@stjude.org
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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